Fu Huafeng, Zhang Jian, Cai Qinbo, He Yulong, Yang Dongjie
Center for Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Digestive Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Cancers (Basel). 2022 Aug 17;14(16):3981. doi: 10.3390/cancers14163981.
The atrial natriuretic peptide (ANP), a cardiovascular hormone, plays a pivotal role in the homeostatic control of blood pressure, electrolytes, and water balance and is approved to treat congestive heart failure. In addition, there is a growing realization that ANPs might be related to immune response and tumor growth. The anti-inflammatory and immune-modulatory effects of ANPs in the tissue microenvironment are mediated through autocrine or paracrine mechanisms, which further suppress tumorigenesis. In cancers, ANPs show anti-proliferative effects through several molecular pathways. Furthermore, ANPs attenuate the side effects of cancer therapy. Therefore, ANPs act on several hallmarks of cancer, such as inflammation, angiogenesis, sustained tumor growth, and metastasis. In this review, we summarized the contributions of ANPs in diverse aspects of the immune system and the molecular mechanisms underlying the anti-cancer effects of ANPs.
心房利钠肽（ANP）是一种心血管激素，在血压、电解质和水平衡的稳态控制中起关键作用，已被批准用于治疗充血性心力衰竭。此外，人们越来越认识到ANP可能与免疫反应和肿瘤生长有关。ANP在组织微环境中的抗炎和免疫调节作用是通过自分泌或旁分泌机制介导的，这进一步抑制了肿瘤发生。在癌症中，ANP通过多种分子途径发挥抗增殖作用。此外，ANP可减轻癌症治疗的副作用。因此，ANP作用于癌症的几个特征，如炎症、血管生成、肿瘤持续生长和转移。在这篇综述中，我们总结了ANP在免疫系统不同方面的作用以及ANP抗癌作用的分子机制。
