Wada Toshiaki, Kawada Kenji, Hanada Keita, Obama Kazutaka
Department of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Department of Surgery, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.
Cancers (Basel). 2022 Aug 20;14(16):4024. doi: 10.3390/cancers14164024.
Forty-three rats were randomly assigned to the following four groups: non-ischemic group (Control Group), 1 cm-long ischemic group (Group 1), 2 cm-long ischemic group (Group 2), and 3 cm-long ischemic group (Group 3). The rates of AL were 0% (0/10) in the Control Group, 22.2% (2/9) in Group 1, 25% (2/8) in Group 2, and 50% (4/8) in Group 3. The bursting pressure of the Control Group was significantly higher than that of the other groups (p < 0.01). Regarding the pathological findings, the granulation thickness and the number of blood vessels at the anastomosed site were significantly higher in the Control Group than in Group 3 (p < 0.05). Receiver operating characteristics analysis revealed that Slope was the most significant predictor of AL, with an area under the curve of 0.861. When the cutoff value of Slope was 0.4, the sensitivity and specificity for the prediction of AL were 75% and 81.4%, respectively. Quantitative analysis of ICG fluorescence angiography could predict AL in a rat model.
43只大鼠被随机分为以下四组：非缺血组（对照组）、1厘米长缺血组（第1组）、2厘米长缺血组（第2组）和3厘米长缺血组（第3组）。吻合口漏发生率在对照组为0%（0/10），第1组为22.2%（2/9），第2组为25%（2/8），第3组为50%（4/8）。对照组的破裂压力显著高于其他组（p<0.01）。关于病理结果，吻合部位的肉芽厚度和血管数量在对照组显著高于第3组（p<0.05）。受试者工作特征分析显示，斜率是吻合口漏最显著的预测指标，曲线下面积为0.861。当斜率的截断值为0.4时，预测吻合口漏的敏感性和特异性分别为75%和81.4%。吲哚菁绿荧光血管造影的定量分析可在大鼠模型中预测吻合口漏。
