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大鼠雪旺细胞对脱髓鞘猫中枢神经系统轴突的再髓鞘化:中枢神经系统组织细胞悬液注射导致雪旺细胞再髓鞘化的证据。

Rat Schwann cell remyelination of demyelinated cat CNS axons: evidence that injection of cell suspensions of CNS tissue results in Schwann cell remyelination.

作者信息

Blakemore W F, Crang A J, Evans R J, Patterson R C

出版信息

Neurosci Lett. 1987 Jun 1;77(1):15-9. doi: 10.1016/0304-3940(87)90599-4.

Abstract

Injection of a suspension of embryonic rat central nervous system (CNS) cells into an area of persistent demyelination, produced in the cat spinal cord by injecting ethidium bromide into an area previously exposed to 40 Grays of x-irradiation, results, initially, in Schwann cell remyelination of the demyelinated axons. However, the Schwann cells are subsequently rejected; a response which confirms that the remyelinating cells are of rat origin.

摘要

将胚胎大鼠中枢神经系统(CNS)细胞悬液注射到猫脊髓中持续脱髓鞘的区域,该区域是通过将溴化乙锭注射到先前接受40格雷X射线照射的区域而产生的,最初会导致脱髓鞘轴突的雪旺细胞重新髓鞘化。然而,雪旺细胞随后会被排斥;这一反应证实了重新髓鞘化的细胞来自大鼠。

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