Sun Chunping, Wang Qingya, Dong Yujun, Nong Lin, Cai Yunlong, Wang Lihong, Sun Yuhua, Wang Wensheng, Liu Xinmin
Department of Geriatric, Peking University First Hospital, Peking University, Beijing 100034, China.
Department of Hematology, Peking University First Hospital, Peking University, Beijing 100034, China.
J Clin Med. 2022 Aug 21;11(16):4915. doi: 10.3390/jcm11164915.
Primary EBV-positive mucocutaneous ulcer (EBVMCU) is a rare and indolent disorder occurring in the oropharynx, skin, and gastrointestinal tract, with remission after removal of the immunosuppressive causes. We present a 69-year-old woman with heartburn, regurgitation of gastric acid, enlarged lymph nodes, and parotid glands. The endoscopic examination showed a circumscribed ulcer in the lower esophagus. A biopsy pathology indicated an esophageal EBV-associated lymphoproliferative disorder and a parotid gland/lymph node indolent B-cell lymphoma. Interestingly, the patient did not undergo any treatment, but the endoscopic ulcer improved significantly after more than 2 months. The last pathology showed EBV negativity, and EBVMCU was considered in combination with clinical and endoscopic manifestations. We followed up with the patient at 6 months, and the symptoms of acid reflux and heartburn had disappeared. Our case demonstrates that EBVMCU may occur in the esophagus with spontaneous regression.
原发性EB病毒阳性黏膜皮肤溃疡（EBVMCU）是一种罕见的惰性疾病，发生于口咽、皮肤和胃肠道，去除免疫抑制病因后可缓解。我们报告一名69岁女性，有烧心、胃酸反流、淋巴结肿大及腮腺肿大症状。内镜检查显示食管下段有一个边界清晰的溃疡。活检病理提示食管EB病毒相关淋巴增殖性疾病及腮腺/淋巴结惰性B细胞淋巴瘤。有趣的是，该患者未接受任何治疗，但2个多月后内镜下溃疡明显改善。最后病理显示EB病毒阴性，结合临床和内镜表现考虑为EBVMCU。我们对患者进行了6个月的随访，反酸和烧心症状已消失。我们的病例表明，EBVMCU可发生于食管并自发消退。
