Lee Seung Hoon, Seo Min Young
Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Ansan 15355, Korea.
Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 02841, Korea.
J Pers Med. 2022 Jul 28;12(8):1234. doi: 10.3390/jpm12081234.
Patients with severe pneumonia of unknown etiology presented in December 2019 in Wuhan, China. A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was isolated from the respiratory tracts of these patients. The World Health Organization (WHO) defined respiratory diseases due to SARS-CoV-2 infection as coronavirus disease 2019 (COVID-19). Many researchers have reported that the nasal cavity is an important initial route for SARS-CoV-2 infection and that the spike protein of this virus binds to angiotensin-converting enzyme 2 (ACE2) on epithelial cell surfaces. Therefore, COVID-19 is thought to significantly affect nasal symptoms and various rhinological diseases. In this review, we summarize the association between COVID-19 and various rhinological diseases, such as olfactory dysfunction, rhinosinusitis, and allergic rhinitis.
2019年12月，中国武汉出现了病因不明的重症肺炎患者。一种新型冠状病毒，即严重急性呼吸综合征冠状病毒2（SARS-CoV-2），从这些患者的呼吸道中分离出来。世界卫生组织（WHO）将SARS-CoV-2感染引起的呼吸道疾病定义为2019冠状病毒病（COVID-19）。许多研究人员报告称，鼻腔是SARS-CoV-2感染的重要初始途径，且该病毒的刺突蛋白与上皮细胞表面的血管紧张素转换酶2（ACE2）结合。因此，COVID-19被认为会显著影响鼻腔症状和各种鼻科疾病。在这篇综述中，我们总结了COVID-19与各种鼻科疾病之间的关联，如嗅觉功能障碍、鼻窦炎和过敏性鼻炎。
