Zhu Weiwei, Long Jiajie, Shi Meiwu
College of Textile and Clothing Engineering, Suzhou University, Suzhou 215127, China.
Materials (Basel). 2022 Aug 12;15(16):5552. doi: 10.3390/ma15165552.
(1) Background: Supercritical CO fluid (SCF-CO)-assisted impregnation presents advantages on loading active drugs to polymer substrates, since it enables the realization of a drug-loaded polymer without any solvent residue. Besides, CO gas and drugs can be recycled and utilized again. Resveratrol-loaded diacetate fiber by SCF-CO-assisted impregnation was done to give diacetate fiber biological activity function for enhancing its added value. (2) Methods: The effect of SCF-CO temperature, pressure and treatment time on loading ability (LA) of resveratrol onto diacetate fiber was explored by ultraviolet visible spectrophotometer. The variation of structure and property of diacetate fiber was analyzed by characterization instruments. (3) Results: LA had been increasing with SCF-CO treatment time, temperature and pressure when SCF-CO was above 70 °C, 12 MPa. The inhibiting rate of resveratrol to free radicals was affected positively by SCF-CO. After resveratrol was impregnated by SCF-CO it appeared some small white granular substances on the surface of diacetate fiber. It had a good interaction between resveratrol and molecular chain of diacetate fiber. (4) Conclusions: Resveratrol was well-loaded onto the diacetate fiber by SCF-CO assisted impregnation.
(1) 背景：超临界CO₂流体（SCF-CO₂）辅助浸渍在将活性药物负载到聚合物基质上具有优势，因为它能够实现无任何溶剂残留的载药聚合物。此外，CO₂气体和药物可以回收再利用。通过SCF-CO₂辅助浸渍制备了负载白藜芦醇的二醋酸纤维，赋予二醋酸纤维生物活性功能以提高其附加值。(2) 方法：采用紫外可见分光光度计探究SCF-CO₂温度、压力和处理时间对白藜芦醇在二醋酸纤维上负载能力（LA）的影响。用表征仪器分析二醋酸纤维结构和性能的变化。(3) 结果：当SCF-CO₂温度高于70℃、压力高于12MPa时，负载能力随SCF-CO₂处理时间、温度和压力的增加而增大。SCF-CO₂对白藜芦醇对自由基的抑制率有积极影响。白藜芦醇经SCF-CO₂浸渍后，二醋酸纤维表面出现一些白色小颗粒物质。白藜芦醇与二醋酸纤维分子链之间有良好的相互作用。(4) 结论：通过SCF-CO₂辅助浸渍，白藜芦醇良好地负载到了二醋酸纤维上。
