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基于 NMR 代谢组学的视角探讨中药治疗啮齿动物糖尿病的潜在作用机制：综述

Potential Therapeutic Mechanism of Traditional Chinese Medicine on Diabetes in Rodents: A Review from an NMR-Based Metabolomics Perspective.

机构信息

Department of Endocrinology, Pingyang Affiliated Hospital of Wenzhou Medical University, Wenzhou 325400, China.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

出版信息

Molecules. 2022 Aug 11;27(16):5109. doi: 10.3390/molecules27165109.

DOI:10.3390/molecules27165109
PMID:36014349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9414875/
Abstract

Traditional Chinese medicine (TCM) has been used to treat diabetes for a long time, but its application has not been widely accepted due to unstandardized product quality and complex pharmacological mechanisms. The modernization of TCM is crucial for its further development, and in recent years the metabolomics technique has largely driven its modernization. This review focuses on the application of NMR-based metabolomics in diabetic therapy using TCM. We identified a series of metabolic pathways that altered significantly after TCM treatment, providing a better understanding of the metabolic mechanisms of TCM for diabetes care.

摘要

中药（TCM）长期以来一直用于治疗糖尿病，但由于产品质量不规范和药理机制复杂，其应用并未得到广泛认可。TCM 的现代化对于其进一步发展至关重要，近年来代谢组学技术在很大程度上推动了其现代化。本综述重点介绍了基于 NMR 的代谢组学在 TCM 治疗糖尿病中的应用。我们确定了一系列在 TCM 治疗后明显改变的代谢途径，为更好地理解 TCM 治疗糖尿病的代谢机制提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/54a598692244/molecules-27-05109-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/c3ab76b493a6/molecules-27-05109-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/8ee2d8f3e841/molecules-27-05109-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/7af125db7bd2/molecules-27-05109-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/b0717bc4d215/molecules-27-05109-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/96e1ed5062e5/molecules-27-05109-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/54a598692244/molecules-27-05109-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/4d0d85fcc00a/molecules-27-05109-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/435cbda95d95/molecules-27-05109-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/ba808d7e6ee1/molecules-27-05109-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/40a7f12dd344/molecules-27-05109-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/c3ab76b493a6/molecules-27-05109-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/8ee2d8f3e841/molecules-27-05109-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/7af125db7bd2/molecules-27-05109-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/b0717bc4d215/molecules-27-05109-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/11f7a1ef39b2/molecules-27-05109-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/d82c1dbd5aec/molecules-27-05109-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/96e1ed5062e5/molecules-27-05109-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a22/9414875/54a598692244/molecules-27-05109-g012.jpg

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