He Yun, Gao Hongjie, Liu Jiankang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Nanomaterials (Basel). 2022 Aug 18;12(16):2834. doi: 10.3390/nano12162834.
Diclofenac is a non-steroidal, anti-inflammatory drug and is clinically used for the treatment of osteoarthritis, non-articular rheumatism, etc. This research aimed to demonstrate the creation of an upgraded photoelectrochemical (PEC) aptamer sensor for detecting diclofenac (DCF) with high sensitivity. In this work, photoactive materials and bio-identification components served as visible-light-active CuS/MoS/BiWO heterostructures and aptamers, respectively. CuS and MoS/BiWO were combined to improve photocurrent responsiveness, which helped the structure of PEC aptasensors. Additionally, the one-pot synthesis of CuS/MoS/BiWO was ecologically beneficial. With these optimizations, the photocurrent response of aptamer/CS/CuS/MoS/BiWO exhibited linearity between 0.1 and 500 nM DCF. The detection limit was 0.03 nM (S/N = 3). These results suggest that the PEC sensing technique might produce an ultra-sensitive sensor with high selectivity and stability for DCF detection.
双氯芬酸是一种非甾体抗炎药，临床上用于治疗骨关节炎、非关节性风湿病等。本研究旨在展示一种升级版的光电化学（PEC）适体传感器的构建，用于高灵敏度检测双氯芬酸（DCF）。在这项工作中，光活性材料和生物识别组件分别为可见光活性的CuS/MoS/BiWO异质结构和适体。CuS与MoS/BiWO相结合以提高光电流响应性，这有助于PEC适体传感器的结构。此外，CuS/MoS/BiWO的一锅合成具有生态效益。通过这些优化，适体/CS/CuS/MoS/BiWO的光电流响应在0.1至500 nM DCF之间呈现线性。检测限为0.03 nM（S/N = 3）。这些结果表明，PEC传感技术可能会产生一种用于DCF检测的具有高选择性和稳定性的超灵敏传感器。
