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载有地塞米松的纳米结构脂质载体可预防原代非实质肝细胞中的炎症反应。

Nanostructured Lipid Carriers Loaded with Dexamethasone Prevent Inflammatory Responses in Primary Non-Parenchymal Liver Cells.

作者信息

Medina-Montano Carolina, Rivero Berti Ignacio, Gambaro Rocío C, Limeres María José, Svensson Malin, Padula Gisel, Chain Cecilia Y, Cisneros José Sebastián, Castro Guillermo R, Grabbe Stephan, Bros Matthias, Gehring Stephan, Islan German A, Cacicedo Maximiliano L

机构信息

Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.

Laboratorio de Nanobiomateriales, Centro de Investigación y Desarrollo en Fermentaciones Industriales (CINDEFI), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP)-CONICET (CCT La Plata), Calle 47 y 115, La Plata B1900, Argentina.

出版信息

Pharmaceutics. 2022 Aug 2;14(8):1611. doi: 10.3390/pharmaceutics14081611.

DOI:10.3390/pharmaceutics14081611
PMID:36015237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9413549/
Abstract

Liver inflammation represents a major clinical problem in a wide range of pathologies. Among the strategies to prevent liver failure, dexamethasone (DXM) has been widely used to suppress inflammatory responses. The use of nanocarriers for encapsulation and sustained release of glucocorticoids to liver cells could provide a solution to prevent severe side effects associated with systemic delivery as the conventional treatment regime. Here we describe a nanostructured lipid carrier developed to efficiently encapsulate and release DXM. This nano-formulation proved to be stable over time, did not interact in vitro with plasma opsonins, and was well tolerated by primary non-parenchymal liver cells (NPCs). Released DXM preserved its pharmacological activity, as evidenced by inducing robust anti-inflammatory responses in NPCs. Taken together, nanostructured lipid carriers may constitute a reliable platform for the delivery of DXM to treat pathologies associated with chronic liver inflammation.

摘要

肝脏炎症是多种病理状况下的一个主要临床问题。在预防肝衰竭的策略中，地塞米松（DXM）已被广泛用于抑制炎症反应。使用纳米载体将糖皮质激素封装并持续释放到肝细胞中，可以解决传统治疗方案中与全身给药相关的严重副作用问题。在此，我们描述了一种开发用于有效封装和释放DXM的纳米结构脂质载体。这种纳米制剂经证明随时间推移是稳定的，在体外不与血浆调理素相互作用，并且原代非实质肝细胞（NPC）对其耐受性良好。释放的DXM保留了其药理活性，这在NPC中诱导强烈的抗炎反应得到了证明。综上所述，纳米结构脂质载体可能构成一个可靠的平台，用于递送DXM以治疗与慢性肝脏炎症相关的病症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/e9c2d3052270/pharmaceutics-14-01611-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/9287f9f264e8/pharmaceutics-14-01611-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/13237b0e068f/pharmaceutics-14-01611-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/14f94ab2b249/pharmaceutics-14-01611-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/8e29d1a33902/pharmaceutics-14-01611-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/061c610ec88c/pharmaceutics-14-01611-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/dbf752fd1229/pharmaceutics-14-01611-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/a10920725d06/pharmaceutics-14-01611-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/229cff5da958/pharmaceutics-14-01611-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/e9c2d3052270/pharmaceutics-14-01611-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/9287f9f264e8/pharmaceutics-14-01611-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/13237b0e068f/pharmaceutics-14-01611-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/14f94ab2b249/pharmaceutics-14-01611-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/8e29d1a33902/pharmaceutics-14-01611-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/061c610ec88c/pharmaceutics-14-01611-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/dbf752fd1229/pharmaceutics-14-01611-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/a10920725d06/pharmaceutics-14-01611-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/229cff5da958/pharmaceutics-14-01611-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/9413549/e9c2d3052270/pharmaceutics-14-01611-g009.jpg

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