Puthanakit Thanyawee, Anugulruengkitt Suvaporn, Angsuwatcharakon Piyada, Bunjoungmanee Pornumpa, Kowitdamrong Ekasit, Primsirikunawut Athiwat, Intarakhao Sukkrawan, Chetsonwisorn Panadda, Sophonphan Jiratchaya, Tangsathapornpong Auchara
Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Center of Excellence for Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Bangkok 10330, Thailand.
Vaccines (Basel). 2022 Aug 6;10(8):1269. doi: 10.3390/vaccines10081269.
To achieve the goal of measles elimination, herd immunity with 95% seroprotection in the community is required. This study aimed to describe the measles seropositivity rate among Thai children and adolescents. A cross-sectional study was conducted among children aged 3−18 years in Bangkok and its suburbs. Measles IgG antibodies were measured using a EUROIMMUN enzyme-linked immunosorbent assay kit. Seropositivity is defined as a measles IgG titer of ≥200 IU/L, due to a correlation with a >85% positive rate with a plaque reduction neutralizing titer of >120. Factors associated with seropositivity were analyzed using logistic regression analysis. From May to July 2020, 570 children with a median (IQR) age of 11.7 (9.4−14.8) years were enrolled. The geometric mean titer (GMT) of anti-measles IgG was 281 IU/L (95% CI; 257−306). The proportion of children with seropositivity was inversely correlated with age; 3−5 years 85.3%, 6−9 years 72.5%, 10−14 years 50.7%, and 15−18 years 56.3%. Adolescents aged 10−18 years had a lower measles seropositivity rate compared with young children; aOR 0.29 (95% CI 0.17−0.48). Only half of the adolescents who received two doses of measles-containing vaccine maintained measles IgG above the seropositive level. A measles booster dose for young adults may be needed to achieve the measles elimination goal.
为实现消除麻疹的目标，社区需达到95%血清保护率的群体免疫。本研究旨在描述泰国儿童和青少年的麻疹血清阳性率。在曼谷及其郊区对3至18岁儿童进行了一项横断面研究。使用欧蒙酶联免疫吸附测定试剂盒检测麻疹IgG抗体。血清阳性定义为麻疹IgG滴度≥200 IU/L，因为其与蚀斑减少中和滴度>120时>85%的阳性率相关。采用逻辑回归分析与血清阳性相关的因素。2020年5月至7月，纳入了570名年龄中位数（IQR）为11.7（9.4 - 14.8）岁的儿童。抗麻疹IgG的几何平均滴度（GMT）为281 IU/L（95%CI；257 - 306）。血清阳性儿童的比例与年龄呈负相关；3至5岁为85.3%，6至9岁为72.5%，10至14岁为50.7%，15至18岁为56.3%。与幼儿相比，10至18岁青少年的麻疹血清阳性率较低；调整后比值比（aOR）为0.29（95%CI 0.17 - 0.48）。仅一半接种两剂含麻疹疫苗的青少年维持麻疹IgG高于血清阳性水平。可能需要为年轻人接种麻疹加强剂以实现消除麻疹的目标。
