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益益附子散活性成分同源疗法治疗冠心病和类风湿关节炎异病同治的潜在机制研究

Study on the potential mechanism of the active components in YiYiFuZi powder in homotherapy for hetropathy of coronary heart disease and rheumatoid arthritis.

作者信息

Wang Yuming, Li Xiaokai, Gu Kun, Gou Jing, Li Xue, Dong Yaqian, Li Rui, Wei Jinxia, Dou Zhiying, Li Yubo

机构信息

Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Ningbo Institute of Life and Health Industry, University of Chinese Academy of Science, Ningbo, Zhejiang, China.

出版信息

Front Chem. 2022 Aug 9;10:926950. doi: 10.3389/fchem.2022.926950. eCollection 2022.

DOI:10.3389/fchem.2022.926950
PMID:36017167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9395646/
Abstract

In recent years, the incidence of coronary heart disease and rheumatoid arthritis has been increasing, which has become a common public health problem worldwide. YiYiFuZi (YYFZ ) powder is a classical traditional Chinese prescription, which is commonly used to treat metabolic diseases such as rheumatoid arthritis, with an ideal curative effect, but the therapeutic mechanism is still unclear. In this study, from the perspective of clinical metabolomics, combined with network pharmacology, we sought the comorbidity mechanism and key targets of coronary heart disease and rheumatoid arthritis and the mechanism by which YYFZ powder exerts therapeutic effects, combined with molecular docking and atomic force microscopy to determine the effective components, and found that the higenamine and steroid components in YYFZ powder can bind acid sphingomyelinase enzymes to affect the sphingolipid pathway to produce therapeutic effects, which can bind to sugars existing as a glycoside.

摘要

近年来，冠心病和类风湿关节炎的发病率不断上升，已成为全球常见的公共卫生问题。益益附子（YYFZ）散是经典的中药方剂，常用于治疗类风湿关节炎等代谢性疾病，疗效理想，但治疗机制尚不清楚。本研究从临床代谢组学角度，结合网络药理学，探寻冠心病和类风湿关节炎的共病机制及关键靶点，以及YYFZ散发挥治疗作用的机制，结合分子对接和原子力显微镜确定有效成分，发现YYFZ散中的去甲乌药碱和甾体成分可与酸性鞘磷脂酶结合，影响鞘脂途径产生治疗作用，其可与以糖苷形式存在的糖类结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/f66ba71eb8f2/fchem-10-926950-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/f00e023e5fd2/fchem-10-926950-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/745a9caece9f/fchem-10-926950-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/6d1bef2fb3b3/fchem-10-926950-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/d5b55b43fb6e/fchem-10-926950-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/f66ba71eb8f2/fchem-10-926950-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/4689bc3b5dac/fchem-10-926950-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/7b2adc92656d/fchem-10-926950-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/71b9f1a9144c/fchem-10-926950-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/3ba5da751bef/fchem-10-926950-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/cec99b8f8ccd/fchem-10-926950-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/c60847ad86ca/fchem-10-926950-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/3f98bd33aed5/fchem-10-926950-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/f00e023e5fd2/fchem-10-926950-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/745a9caece9f/fchem-10-926950-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c50/9395646/f66ba71eb8f2/fchem-10-926950-g014.jpg

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