Li Yihan, Wang Yingfan, Jiang Ping, Sun Jintao, Chen Qiqi, Wang Xiaoshan
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
MEG Center, Nanjing Brain Hospital, Nanjing, China.
Front Neurosci. 2022 Aug 9;16:944391. doi: 10.3389/fnins.2022.944391. eCollection 2022.
Rolandic epilepsy (RE) is one of the most common epilepsy syndromes during childhood. The aim of this study was to investigate the alterations in the default mode network (DMN) of RE patients whose spike-wave index (SWI) was within the 50-85% range during non-rapid eye movement (NREM) during sleep, as well as to detect early neuroimaging markers.
Resting-state data was recorded for each subject using magnetoencephalography (MEG). DMN-related brain regions were chosen as regions of interest. The spectral power and functional connectivity (FC) of the DMN were estimated through the use of minimum norm estimation (MNE) combined with Welch technique and corrected amplitude envelope correlation (AEC-c).
The patient group included 20 patients with NREM phase 50% ≤ SWI < 85% (mild SWI group), and 18 typical RE patients (SWI < 50% group). At the regional level, the mild SWI group exhibited enhanced spectral power in the delta band of the bilateral posterial cingulate cortex and attenuated the spectral power in the alpha band of the bilateral posterial cingulate cortex. Enhanced spectral power in the bilateral precuneus (PCu) in the delta band and attenuated spectral power in the right lateral temporal cortex (LTC) in the alpha band were common across all RE patients. At the FC level, patients in the mild SWI group indicated increased AEC-c values between the bilateral posterial cingulate cortex in the delta band and between the left medial frontal cortex (MFC) and bilateral posterial cingulate cortex in the alpha band. Increased AEC-c values between the right PCu and left MFC in the delta band, and between the left PCu and right MFC in the theta band, were common across all RE patients. Moreover, the spectral power in the bilateral posterial cingulate cortex in the alpha band and the AEC-c value between the bilateral posterial cingulate cortex in the delta band demonstrated good discrimination ability.
The spectral power of the bilateral posterior cingulate cortex (PCC) in the alpha band and the AEC-c value between the bilateral PCC in the delta band may be promising indicators of early differentiation between mild SWI and typical RE.
罗兰多癫痫（RE）是儿童期最常见的癫痫综合征之一。本研究旨在调查睡眠非快速眼动（NREM）期间棘波指数（SWI）在50%-85%范围内的RE患者默认模式网络（DMN）的改变，以及检测早期神经影像学标志物。
使用脑磁图（MEG）记录每个受试者的静息态数据。选择与DMN相关的脑区作为感兴趣区。通过使用最小范数估计（MNE）结合韦尔奇技术和校正幅度包络相关（AEC-c）来估计DMN的频谱功率和功能连接（FC）。
患者组包括20例NREM期50%≤SWI<85%的患者（轻度SWI组）和18例典型RE患者（SWI<50%组）。在区域水平上，轻度SWI组双侧后扣带回皮质δ波段的频谱功率增强，双侧后扣带回皮质α波段的频谱功率减弱。所有RE患者双侧楔前叶（PCu）δ波段的频谱功率增强，右侧颞叶外侧皮质（LTC）α波段的频谱功率减弱。在FC水平上，轻度SWI组患者双侧后扣带回皮质δ波段之间以及左侧内侧额叶皮质（MFC）与双侧后扣带回皮质α波段之间的AEC-c值增加。所有RE患者右侧PCu与左侧MFC之间δ波段以及左侧PCu与右侧MFC之间θ波段的AEC-c值增加。此外，双侧后扣带回皮质α波段的频谱功率以及双侧后扣带回皮质δ波段之间的AEC-c值具有良好的辨别能力。
双侧后扣带回皮质（PCC）α波段的频谱功率以及双侧PCC之间δ波段的AEC-c值可能是轻度SWI与典型RE早期鉴别的有前景的指标。
