Okobi Okelue E, Agazie Ogochukwu, Ayisire Oghenetega E, Babalola Funmilola, Dick Anthony I, Akinsola Zainab, Adeosun Adeyemi A, Owolabi Oluwasayo J, Ajayi Temitope O, Odueke Adetayo Y
Family Medicine, Lakeside Medical Center, Belle Glade, USA.
Medicine, College of Medicine University of Lagos, Idi Araba, NGA.
Cureus. 2022 Jul 22;14(7):e27143. doi: 10.7759/cureus.27143. eCollection 2022 Jul.
Lack of insight typically complicates psychiatric presentations, necessitating careful thought and planning to choose the best course of treatment. Exploring methods of medication administration techniques in the context of a lack of insight is crucial to achieving the ultimate goal of overcoming the insight barrier as rapidly as possible, which will result in therapeutic benefit. This study's objective was to systematically review the evidence on medication administration techniques in a backdrop of lack of insight and how that evidence was curated in the scientific literature. This study used the literature search strategy, which entails retrieving and analyzing the existing scientific literature pertinent to medication administration techniques for individuals with no insight between 2010 and 2022. Accessing online databases, such as PubMed, Google Scholar, and Medline was utilized in this study's literature search strategy. In our findings, in the primary evidence search, no randomized control trial (RCT) comparing the various models of medication administration with a lack of insight was found. No study provided data on the superiority of utility, quality of life, or efficacy outcome. Some 17 scientific papers were identified that cited various trials about lack of insight and medication use and met the inclusion criteria. We concluded that it could be challenging to administer medication to patients who lack insight. Nonetheless, progress has been made to mitigate this obstacle. Common moral values, common sense, medicolegal support, person-centered integrated care, and cutting-edge medication techniques may play a role. However, these models of medication administration are still evolving, along with the ethical concerns accompanying them. Hopefully, the available models discussed in this analysis will serve as a foundation for future developments. Nonetheless, much remains to be done. We encourage contemporary research to investigate safer and more dynamic methods that can alleviate this condition.
缺乏自知力通常会使精神科症状复杂化，因此需要仔细思考和规划以选择最佳治疗方案。在缺乏自知力的情况下探索药物给药技术的方法对于尽快克服自知力障碍这一最终目标至关重要，而这将带来治疗益处。本研究的目的是系统回顾在缺乏自知力背景下有关药物给药技术的证据，以及该证据在科学文献中的整理情况。本研究采用文献检索策略，即检索和分析2010年至2022年间与缺乏自知力个体的药物给药技术相关的现有科学文献。本研究的文献检索策略利用了在线数据库，如PubMed、谷歌学术和Medline。在我们的研究结果中，在初步证据搜索中，未发现比较各种缺乏自知力情况下药物给药模式的随机对照试验（RCT）。没有研究提供关于效用优越性、生活质量或疗效结果的数据。共识别出17篇科学论文，这些论文引用了各种关于缺乏自知力和药物使用的试验并符合纳入标准。我们得出结论，给缺乏自知力的患者给药可能具有挑战性。尽管如此，在减轻这一障碍方面已经取得了进展。共同的道德价值观、常识、法医学支持、以患者为中心的综合护理和前沿的药物技术可能发挥作用。然而，这些药物给药模式仍在不断发展，与之相伴的伦理问题也在发展。希望本分析中讨论的现有模式能为未来发展奠定基础。尽管如此，仍有许多工作要做。我们鼓励当代研究探索更安全、更具活力的方法来缓解这种情况。
