Yang Heng, Chiang Chengyao, Luo Qinhong, Chen Chunlan, Huang Junrong, Zhu Lizhi, Zheng Duo
Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Shenzhen University International Cancer Center, Department of Cell Biology and Genetics, School of Medicine, Department of Pharmacy, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen University, Shenzhen, China.
Central Laboratory, Southern University of Science and Technology, Yantain Hospital, Shenzhen, China.
Front Genet. 2022 Aug 9;13:934223. doi: 10.3389/fgene.2022.934223. eCollection 2022.
N6-methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic mRNA and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma, through varied mechanisms. As direct m6A readers, the YT521-B homology domain family proteins (YTHDFs) play a key role in tumor transcription, translation, protein synthesis, tumor stemness, epithelial-mesenchymal transition (EMT), immune escape, and chemotherapy resistance. An in-depth understanding of the molecular mechanism of YTHDFs is expected to provide new strategies for tumor treatment. In this review, we provide a systematic description of YTHDF protein structure and its function in tumor progression.
N6-甲基腺苷（m6A）是真核生物mRNA中最丰富的内部化学修饰，在基因调控中发挥多种作用。m6A修饰通过多种机制在包括肾、胃、肺、膀胱肿瘤和黑色素瘤在内的多种癌症类型中发挥重要作用。作为直接的m6A阅读器，YT521-B同源结构域家族蛋白（YTHDFs）在肿瘤转录、翻译、蛋白质合成、肿瘤干性、上皮-间质转化（EMT）、免疫逃逸和化疗耐药中起关键作用。深入了解YTHDFs的分子机制有望为肿瘤治疗提供新策略。在本综述中，我们系统描述了YTHDF蛋白结构及其在肿瘤进展中的功能。
