Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis.

PURPOSE

This study aims to evaluate the accuracy of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in distinguishing malignant and benign solitary pulmonary nodules and masses.

METHODS

Studies investigating the diagnostic accuracy of IVIM-DWI in lung lesions published through December 2020 were searched. The standardized mean differences (SMDs) of the apparent diffusion coefficient (ADC), tissue diffusivity (), pseudo-diffusivity (*), and perfusion fraction () were calculated. The sensitivity, specificity, area under the curve (AUC), publication bias, and heterogeneity were then summarized, and the source of heterogeneity and the reliability of combined results were explored by meta-regression and sensitivity analysis.

RESULTS

A total of 16 studies including 714 malignant and 355 benign lesions were included. Significantly lower ADC, , and values were found in malignant pulmonary lesions compared to those in benign lesions. The value showed the best diagnostic performance (sensitivity = 0.90, specificity = 0.71, AUC = 0.91), followed by ADC (sensitivity = 0.84, specificity = 0.75, AUC = 0.88), (sensitivity = 0.70, specificity = 0.62, AUC = 0.71), and (sensitivity = 0.67, specificity = 0.61, AUC = 0.67). There was an inconspicuous publication bias in ADC, , * and values, moderate heterogeneity in ADC, and high heterogeneity in , *, and values. Subgroup analysis suggested that both ADC and values had a significant higher sensitivity in "nodules or masses" than that in "nodules."

CONCLUSIONS

The parameters derived from IVIM-DWI, especially the value, could further improve the differential diagnosis between malignant and benign solitary pulmonary nodules and masses. https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier: CRD42021226664.