12277Duke University School of Medicine, Durham, NC, USA.
26625University of Toronto, Toronto, ON, Canada.
Lupus. 2022 Oct;31(11):1401-1407. doi: 10.1177/09612033221123251. Epub 2022 Aug 26.
We evaluated the association of lupus nephritis (LN) and adverse pregnancy outcomes in prospective cohorts of pregnant women with SLE (systemic lupus erythematosus).
We conducted a patient-level pooled analysis of data from three cohorts of pregnant women with SLE. Pooled logistic regression models were used to evaluate the association of LN and adverse pregnancy outcomes. Odds ratios and 95% confidence intervals were calculated using a fixed effect model by enrolling cohort.
The pooled cohort included 393 women who received care at clinics in the United States and Canada from 1995 to 2015. There were 144 (37%) women with a history of LN. Compared to women without LN, those with LN had higher odds of fetal loss (OR: 1.90; 95% CI: 1.01, 3.56) and preeclampsia (OR: 2.04; 95% CI: 1.01, 4.13). Among the 31 women with active nephritis (defined as urine protein ≥ 0.5 g/24 h) there was a higher odds of poor pregnancy outcome (OR: 3.08; 95% CI: 1.31, 7.23) and fetal loss (OR: 6.29; 95% CI: 2.52, 15.70) compared to women without LN.
In this pooled cohort of women with SLE, a history of LN was associated with fetal loss and preeclampsia. Active nephritis was associated with poor pregnancy outcome and fetal loss.
我们评估了狼疮肾炎（LN）与系统性红斑狼疮（SLE）孕妇前瞻性队列中不良妊娠结局的关联。
我们对来自三个 SLE 孕妇队列的数据进行了患者水平的汇总分析。使用汇总逻辑回归模型评估 LN 与不良妊娠结局的关联。使用固定效应模型通过纳入队列计算比值比和 95%置信区间。
汇总队列包括 1995 年至 2015 年在美国和加拿大诊所就诊的 393 名妇女。有 144 名（37%）妇女有 LN 病史。与无 LN 的妇女相比，LN 妇女发生胎儿丢失的几率更高（比值比：1.90；95%置信区间：1.01，3.56）和子痫前期（比值比：2.04；95%置信区间：1.01，4.13）。在 31 名患有活动性肾炎（定义为尿蛋白≥0.5g/24h）的妇女中，妊娠结局不良（比值比：3.08；95%置信区间：1.31，7.23）和胎儿丢失（比值比：6.29；95%置信区间：2.52，15.70）的几率高于无 LN 的妇女。
在这个 SLE 妇女的汇总队列中，LN 病史与胎儿丢失和子痫前期有关。活动性肾炎与不良妊娠结局和胎儿丢失有关。
