Ilgun Ahmet Serkan, Aktepe Fatma, Gonullu Onur, Kapucuoglu Nilgun, Yararbas Kanay, Alco Gul, Ozturk Alper, Elbuken Celebi Filiz, Erdogan Zeynep, Ordu Cetin, Unal Caglar, Duymaz Tomris, Soybir Gursel, Yavuz Ekrem, Tuzlali Sitki, Ozmen Vahit
Department of Surgery, Demiroglu Bilim University, Abide-i Hürriyet Cd No:164, Şişli/Istanbul, 34387, Turkey.
Department of Pathology, Sisli Memorial Hospital, Istanbul, 34384, Turkey.
Future Oncol. 2022 Sep;18(29):3289-3298. doi: 10.2217/fon-2022-0157. Epub 2022 Aug 26.
This study investigated the effect of neoadjuvant chemotherapy (NAC) on stromal tumor-infiltrating lymphocytes (sTILs) and their treatment response. 115 patients with pre-NAC core biopsies and post-NAC surgical resection specimens were reviewed. There was no significant change between pre- and post-treatment sTILs. Both pre- and post-NAC sTILs were significantly lower in patients with luminal A subtype. An increase in sTILs was observed in 21 (25.9%) patients after NAC, a decrease in 29 (35.8%) and no change in 31 (38.3%; p = 0.07). Pretreatment sTIL density was independent predictor of pathological complete response in multivariate analyses (odds ratio: 1.025, 95% CI: 1.003-1.047; p = 0.023). High sTIL density in core biopsies was independently related to pathological complete response. In addition, ER appears to be the most crucial factor determining the rate of sTIL.
本研究调查了新辅助化疗（NAC）对基质肿瘤浸润淋巴细胞（sTILs）及其治疗反应的影响。回顾了115例接受NAC前核心活检和NAC后手术切除标本的患者。治疗前后的sTILs无显著变化。管腔A型亚型患者治疗前和治疗后的sTILs均显著较低。NAC后，21例（25.9%）患者的sTILs增加，29例（35.8%）患者的sTILs减少，31例（38.3%）患者的sTILs无变化（p = 0.07）。在多变量分析中，治疗前sTIL密度是病理完全缓解的独立预测因素（比值比：1.025，95%可信区间：1.003 - 1.047；p = 0.023）。核心活检中高sTIL密度与病理完全缓解独立相关。此外，雌激素受体（ER）似乎是决定sTIL比率的最关键因素。
