From the Baskent University Faculty of Medicine, Department of Nephrology and Transplantation, Baskent University, Ankara, Turkey.
Exp Clin Transplant. 2022 Aug;20(Suppl 4):62-64. doi: 10.6002/ect.DonorSymp.2022.O4.
Kidney transplant is the best treatment for patients with end-stage renal disease. Preparation of living related kidney donors and recipients is the major step to achieve their best long-term outcomes. Here, we present the Baskent University criteria for living kidney donors and recipients.
The Baskent team has performed >2000 kidney transplants from 1985 to 2022 under leadership of Prof. Mehmet Haberal, a transplantation pioneer in Turkey, who facilitated Turkish legislation on procurement, storage, engraftment, and transplant of organs and tissues in June 1979, which has been adopted in other countries with few changes. Although the main frame is similar, we have constant principles in kidney donation. Baskent University is now known as an exceptional transplant center in Turkey, the Middle East, Europe, and the world and has established its own donor criteria for both kidney and liver transplant.
Volunteerism remains a core principle of living kidney donation, regardless of other criteria. At Baskent University, donor protection from social, psychological, and health problems is paramount. Loss-profit and risk of transplant are assessed for every case. Donors must be followed up and remedies sought for failed criteria. Dr. Haberal's principles are the basis of Baskent University donation criteria, and unrelated kidney transplant donors are accepted only in cases of cross-donation. Major distinctions of Baskent University's living related donor criteria are (1) absence of unrelated or nondirected donation, (2) lowest acceptable donor glomerular filtration rate of 100 mL/min, (3) rejection of hypertensive donor candidates (regardless of medication), and (4) obesity must be corrected before transplant if body mass index (measured as body weight in kilograms divided by height in meters squared) is >30.
The Baskent University donor selection criteria provide excellent long-term outcomes of kidney donors that have been proved by our recent studies.
肾移植是治疗终末期肾病患者的最佳方法。准备活体亲属供者和受者是实现其最佳长期结果的主要步骤。在这里,我们提出了巴肯特大学的活体肾脏供者和受者标准。
在土耳其移植先驱 Mehmet Haberal 教授的领导下,巴肯特团队自 1985 年至 2022 年进行了超过 2000 例肾移植,他于 1979 年 6 月促成了关于器官和组织采购、储存、移植的土耳其立法,该立法在其他国家几乎没有变化的情况下被采用。虽然主要框架相似,但我们在肾脏捐赠方面有恒定的原则。巴肯特大学现在是土耳其、中东、欧洲和世界上的一个杰出移植中心,并为肾和肝移植制定了自己的供者标准。
志愿主义仍然是活体肾脏捐赠的核心原则,无论其他标准如何。在巴肯特大学,保护供者免受社会、心理和健康问题的影响是至关重要的。对每一个病例都要评估收益-损失和移植风险。必须对供者进行随访,并为不符合标准的情况寻求补救措施。哈伯拉尔博士的原则是巴肯特大学捐赠标准的基础,只有在交叉捐赠的情况下才接受非相关或非定向的肾脏移植供者。巴肯特大学活体相关供者标准的主要区别是:(1) 不存在非相关或非定向捐赠;(2) 可接受的最低供者肾小球滤过率为 100ml/min;(3) 拒绝高血压供者候选人(无论药物治疗如何);(4) 如果体重指数(以体重公斤数除以身高米数的平方)>30,则在移植前必须纠正肥胖。
巴肯特大学的供者选择标准为活体供者提供了出色的长期结果,这已被我们最近的研究证明。