Department of Ophthalmology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.
Department of Ophthalmology, L.L.R.M. Medical College, Meerut, Uttar Pradesh, India.
Indian J Ophthalmol. 2022 Sep;70(9):3373-3376. doi: 10.4103/ijo.IJO_256_22.
Myopia is the most common type of refractive error and the leading cause of functional visual loss. Increased risk of myopic maculopathy, retinal detachment, glaucoma and cataract has been seen with a myopia of as low as -1D. This study was done to determine the effect of atropine 0.01% eye drops on the progression of myopia in children >5 years.
This was a single-blind, prospective, randomized case-control study which included children of 5-15 years with myopia of >2D and were divided into treatment group (group 1) and placebo group (group 2). Children under treatment group were treated with application of 0.01% atropine at night. Children with history of any ocular surgery, chronic ophthalmic illness, squint and amblyopia were excluded from the study. The follow-up for myopia progression was done for two years.
This study showed a significant difference in increase of spherical equivalent and axial length among treatment and placebo groups after a duration of two years. Total duration of follow up was twenty-four months. Mean increase in axial length of group 1 and 2 was 0.115 mm and 0.32 mm, respectively. Mean increase in refraction of groups 1 and 2 was -0.30 D and -0.88 D, respectively, showing significant change in axial length and refraction (P < 0.0001).
This study supports the use of atropine 0.01% eye drops in reducing the progression of myopia.
近视是最常见的屈光不正类型，也是导致功能性视力丧失的主要原因。近视程度低至-1D 时，就会增加出现近视性黄斑病变、视网膜脱离、青光眼和白内障的风险。本研究旨在确定 0.01%阿托品滴眼液对 5 岁以上儿童近视进展的影响。
这是一项单盲、前瞻性、随机病例对照研究，纳入了近视>2D 的 5-15 岁儿童，并分为治疗组（第 1 组）和安慰剂组（第 2 组）。治疗组的儿童在夜间使用 0.01%阿托品滴眼。有任何眼部手术、慢性眼病、斜视和弱视史的儿童被排除在研究之外。对近视进展的随访时间为两年。
这项研究显示，在两年的时间里，治疗组和安慰剂组的等效球镜和眼轴长度增加有显著差异。总随访时间为 24 个月。第 1 组和第 2 组的眼轴长度平均增加分别为 0.115mm 和 0.32mm。第 1 组和第 2 组的屈光度平均增加分别为-0.30D 和-0.88D，表明眼轴长度和屈光度有显著变化（P<0.0001）。
本研究支持使用 0.01%阿托品滴眼液来减缓近视的进展。
