Brass E P
Postgrad Med. 1987 Jul;82(1):83-7, 90. doi: 10.1080/00325481.1987.11699896.
When used properly, measurements of plasma drug levels in the clinical setting may provide valuable information. Optimally the drug level will permit the clinician to devise a therapeutic regimen on the basis of an individual patient's handling of the drug and thus obtain maximal drug efficacy while minimizing the risk of drug toxicity. However, the technology that permits the measurement of drug levels has often outpaced the clinical data base that allows proper interpretation of the level. Thus, the physician should be aware of both the potential and the limitations of therapeutic drug monitoring and apply the technique critically with respect to individual drugs in individual patients.
在临床环境中正确使用时，血浆药物水平测量可能会提供有价值的信息。理想情况下，药物水平将使临床医生能够根据个体患者对药物的处理情况制定治疗方案，从而在将药物毒性风险降至最低的同时获得最大的药物疗效。然而，能够测量药物水平的技术往往超越了能够对该水平进行正确解读的临床数据库。因此，医生应该了解治疗药物监测的潜力和局限性，并针对个体患者的个别药物审慎应用该技术。
