Kyogoku M, Nose M, Sawai T, Miyazawa M, Tachiwaki O, Kawashima M
Prog Clin Biol Res. 1987;229:95-130.
Murine lupus is a useful animal model for the study of disease based on some defect in the immune system including the so-called collagen diseases. Seven strains are available in Japan; NZB, NZB/WF1, MRL/Mp-lpr/lpr, BxSB, SL/Ni, NC and C3H/HeJ-gld/gld. Characteristics of these strains of mice are outlined. Care should be taken about applying the knowledge or information obtained from animal models to the analysis of related human disease because there are various genetic or species barriers which cannot be overcome. Therefore, it is rather dangerous to conclude that the pathogenesis of some human disease is similar to that of an animal model from a study of the latter. Therefore, one should divide the data obtained from animal experiments into "factors" and insert each factor in the "formula" of a human disease in order to better understand it. Recent studies by the authors on two strains of lupus mouse; SL/Ni and MRL/Mp-lpr/lpr from such a standpoint are presented and discussed in detail.
小鼠狼疮是一种用于基于免疫系统某些缺陷（包括所谓的胶原病）研究疾病的有用动物模型。在日本有七种品系；NZB、NZB/WF1、MRL/Mp-lpr/lpr、BxSB、SL/Ni、NC和C3H/HeJ-gld/gld。概述了这些品系小鼠的特征。在将从动物模型获得的知识或信息应用于相关人类疾病分析时应谨慎，因为存在各种无法克服的遗传或物种障碍。因此，从对动物模型的研究得出某些人类疾病的发病机制与动物模型相似的结论是相当危险的。因此，为了更好地理解，人们应该将从动物实验获得的数据分解为“因素”，并将每个因素代入人类疾病的“公式”中。作者最近从这样的角度对两种狼疮小鼠品系；SL/Ni和MRL/Mp-lpr/lpr进行的研究进行了详细介绍和讨论。
