Zékány A, Makleit S
Pharmazie. 1987 Mar;42(3):160-1.
Synthesis of new cephalosporins possessing thieno [2,3-d]pyrimidine is described in the present paper. Potassium salts of 2-thio-4-oxo-3,4-dihydrothieno [2,3-d]pyrimidines, which gave then 2-carboxymethylmercapto-4-oxo-3,4-dihydrothieno [2,3-d]pyrimidines, were prepared from 2-amino-3-carbethoxythiophene derivatives. These compounds were allowed to react with 7-aminocephalosporamic acid (ACA) benzhydryl esters or with 7 beta-chloroacetamidocephalosporanic acid derivatives to obtain new cephalosporins. Antibacterial activities of these new cephalosporins are summarized in the present paper as well.
本文描述了具有噻吩并[2,3 - d]嘧啶的新型头孢菌素的合成。由2 - 氨基 - 3 - 乙氧羰基噻吩衍生物制备2 - 硫代 - 4 - 氧代 - 3,4 - 二氢噻吩并[2,3 - d]嘧啶的钾盐，然后得到2 - 羧甲基巯基 - 4 - 氧代 - 3,4 - 二氢噻吩并[2,3 - d]嘧啶。使这些化合物与7 - 氨基头孢烷酸（ACA）二苯甲酯或与7β - 氯乙酰氨基头孢烷酸衍生物反应以获得新型头孢菌素。本文还总结了这些新型头孢菌素的抗菌活性。
