Breslau N, Davis G C, Prabucki K
Psychiatry Res. 1987 Apr;20(4):285-97. doi: 10.1016/0165-1781(87)90089-8.
The diagnostic validity of generalized anxiety disorder (GAD) is tested by examining the relationship between GAD in mothers and children's overanxious disorder (OAD), separation anxiety (SA), and anxious symptoms in 331 mother-child dyads from a geographically based probability sample. Data on the relationship between mothers' major depressive disorder (MDD) and children's depression are presented for comparison. The National Institute of Mental Health (NIMH) Diagnostic Interview Schedule (DIS) was used in mothers and the NIMH Diagnostic Interview Schedule for Children (DISC), in children. Children of mothers with GAD were not at increased risk for OAD, SA, or anxious symptoms. In contrast, MDD in mothers conferred a risk for OAD in younger children and of MDD in older children. Additionally, older children of depressed mothers exhibited significantly more depressive symptoms. The presence of diffuse anxiety in children of mothers with MDD may represent a nonspecific response pattern in psychiatrically vulnerable children. Like GAD in adults, these anxiety symptoms in children may constitute a prodromal manifestation of other disorders and transient responses to life stressors.
通过研究来自基于地理位置的概率样本中的331对母婴二元组中母亲的广泛性焦虑障碍（GAD）与儿童过度焦虑障碍（OAD）、分离焦虑（SA）及焦虑症状之间的关系，来检验GAD的诊断效度。同时给出母亲的重度抑郁症（MDD）与儿童抑郁症之间关系的数据用于比较。母亲使用美国国立精神卫生研究所（NIMH）诊断访谈表（DIS），儿童使用NIMH儿童诊断访谈表（DISC）。患有GAD的母亲的孩子患OAD、SA或出现焦虑症状的风险并未增加。相比之下，母亲患有MDD会使年幼儿童患OAD及年长儿童患MDD的风险增加。此外，母亲患有抑郁症的年长儿童表现出明显更多的抑郁症状。母亲患有MDD的儿童出现的弥漫性焦虑可能代表了精神脆弱儿童的一种非特异性反应模式。与成人的GAD一样，儿童的这些焦虑症状可能构成其他疾病的前驱表现以及对生活应激源的短暂反应。
