Baclofen in the treatment of schizophrenia: a pilot study.

10 chronic schizophrenics were treated with baclofen for 30 days in addition to the neuroleptic maintenance medication. The psychopathological findings were documented in intervals of 5 days using a global rating and the BPRS scale. 3 patients showed a definite slight improvement of their clinical condition, 2 patients showed a questionable improvement, whereas 5 patients did not change. The statistical analysis of the BPRS scale revealed a significant improvement of one higher order factor. Our pilot study suggests that baclofen may have positive effects on some schizophrenics.