Kovalikova Z, Hoehn-Berlage M H, Gersonde K, Porschen R, Mittermayer C, Franke R P
Radiology. 1987 Aug;164(2):543-8. doi: 10.1148/radiology.164.2.3602399.
The T1 and T2 values of adenocarcinoma EO 771 inoculated into the hind leg of mice are characterized and correlated with the histopathologic state of the tumor. Growth-dependent changes (indicated by a T1 of 630-910 msec and a T2 of 68-185 msec) can be separated into four characteristic phases. The increase in relaxation times in the early phases (A and B) is due to an increasing amount of viable tumor tissue relative to normal muscle tissue. In the later phases (C and D), a decline of the relaxation parameters is observed that is parallel to an increase in the fraction of necrotic tissue. By multiexponential analysis, two relaxation components (indicated by and, respectively) for T1 and T2 and the corresponding fractions alpha 1 and alpha 2 can be observed for both tumor and surrounding muscle tissue. A tissue criterion ("magnetic resonance fingerprint") is defined by a combination of these multiple parameters. This criterion allows separation of not only muscle and tumor tissue but also viable (early state) and necrotic (late state) tumor tissue.
将腺癌EO 771接种到小鼠后腿后的T1和T2值被表征，并与肿瘤的组织病理学状态相关联。生长依赖性变化（以T1为630 - 910毫秒和T2为68 - 185毫秒表示）可分为四个特征阶段。早期阶段（A和B）弛豫时间的增加是由于相对于正常肌肉组织，存活肿瘤组织的数量增加。在后期阶段（C和D），观察到弛豫参数下降，这与坏死组织比例的增加平行。通过多指数分析，对于肿瘤和周围肌肉组织，均可观察到T1和T2的两个弛豫成分（分别由和表示）以及相应的分数α1和α2。通过这些多个参数的组合定义了一个组织标准（“磁共振指纹”）。该标准不仅能够区分肌肉和肿瘤组织，还能区分存活（早期状态）和坏死（晚期状态）的肿瘤组织。
