Smith Megan M, Weber Jeremy M, Truong Tracy, Swamy Geeta K, Wheeler Sarahn M
Duke University School of Medicine, Durham, NC, USA.
Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
J Perinat Med. 2022 Aug 29;50(7):970-976. doi: 10.1515/jpm-2021-0425. Print 2022 Sep 27.
The US preterm birth rate varies dramatically by race and ethnicity yet the racial and ethnic representation within studies evaluating 17-hydroxprogesterone caproate (17-P) for preterm birth prevention is unknown. The objectives of our study were to 1) examine the racial and ethnic representation of participants in 17-P preterm birth prevention studies, 2) evaluate adherence to the NIH race and ethnicity reporting guidelines and 3) compare racial and ethnic representation in research studies to national preterm birth incidence.
We systematically reviewed US studies published between January 2000 and December 2019. Study participant's race and ethnicity were reported using descriptive statistics then compared to US 2017//2018 preterm birth data using Pearson's chi-square.
Eighteen studies met the inclusion criteria, 17 studies reported race, 11 studies reported ethnicity, and yet none of the studies followed the NIH criteria. Compared to 2017/2018 US preterm births, the proportion of black/African American study participants was significantly higher whereas the proportions of all other race categories were lower.
More detailed reporting of race and ethnicity is needed in 17-P literature. Black women appear to be well represented while other racial and ethnic groups may be understudied.
美国的早产率因种族和族裔不同而有显著差异，但在评估己酸17-羟孕酮（17-P）预防早产的研究中，种族和族裔代表性情况尚不清楚。我们研究的目的是：1）检查参与17-P预防早产研究的参与者的种族和族裔代表性；2）评估对美国国立卫生研究院（NIH）种族和族裔报告指南的遵循情况；3）比较研究中的种族和族裔代表性与全国早产发生率。
我们系统回顾了2000年1月至2019年12月发表的美国研究。使用描述性统计报告研究参与者的种族和族裔，然后使用Pearson卡方检验与美国2017//2018年早产数据进行比较。
18项研究符合纳入标准，17项研究报告了种族，11项研究报告了族裔，但没有一项研究遵循NIH标准。与2017/2018年美国早产情况相比，黑人/非裔美国研究参与者的比例显著更高，而所有其他种族类别的比例则更低。
17-P文献中需要更详细地报告种族和族裔情况。黑人女性似乎有充分的代表性，而其他种族和族裔群体可能研究不足。
