Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Endocrinology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua Central Hospital, Shenzhen, Guangdong, China.
J Nutr Biochem. 2022 Dec;110:109131. doi: 10.1016/j.jnutbio.2022.109131. Epub 2022 Aug 23.
Clinical studies have demonstrated that maternal gestational diabetes mellitus (GDM) increases the offspring's risk of developing glucose intolerance. Our previous study reported that co-supplementation with zinc, selenium, and chromium improved insulin resistance in diet-induced GDM rats. Here, Transgenerational effects of supplementation with zinc (10 mg/kg.bw), selenium (20 μg/kg.bw), and chromium (20 μg/kg.bw) in F1 female offspring of both zinc, selenium and chromium (ZnSeCr)-treated, and untreated GDM rats daily by gavage from weaning to the postpartum were investigated in the present study. Glucose homeostasis in the F1 female offspring of GDM at different stages were evaluated. Maternal GDM did increase the birth mass of newborn F1 female offspring, as well as the serum glucose and insulin levels. Zinc, selenium and chromium supplementation attenuated the GDM-induced mass gain, increased serum glucose and insulin levels in the female neonates. The high fat and sucrose (HFS) diet-fed GDM-F1 offspring developed GDM, with glucose intolerance, hyperglycemia and insulin resistance during pregnancy. Moreover, endoplasmic reticulum (ER) stress-related protein levels were increased and the activation of insulin signaling pathways were reduced in the liver of HFS-fed GDM-F1 offspring. Whereas glucose homeostasis in parallel with insulin sensitivity was normalized in the female offspring of GDM by supplementation both F0 dams and F1 offspring with zinc, selenium and chromium, not in those either F0 or F1 elements supplemented offspring. Therefore, we speculate that zinc, selenium and chromium supplementation may have a potential beneficial transgenerational effect on the glucose homeostasis in the female offspring of GDM.
临床研究表明，母体妊娠期糖尿病（GDM）会增加后代出现葡萄糖耐量异常的风险。我们之前的研究报告称，锌、硒和铬的联合补充可以改善饮食诱导的 GDM 大鼠的胰岛素抵抗。在这里，我们研究了通过灌胃从断奶到产后每天补充锌（10mg/kg.bw）、硒（20μg/kg.bw）和铬（20μg/kg.bw）对 GDM 大鼠及其未处理的 F1 雌性后代的跨代影响。本研究评估了 GDM 对 F1 雌性后代不同阶段葡萄糖稳态的影响。母体 GDM 确实增加了新生 F1 雌性后代的出生体重，以及血清葡萄糖和胰岛素水平。锌、硒和铬的补充减轻了 GDM 引起的体重增加，增加了雌性新生儿的血清葡萄糖和胰岛素水平。高脂肪和蔗糖（HFS）饮食喂养的 GDM-F1 后代出现 GDM，在怀孕期间出现葡萄糖耐量异常、高血糖和胰岛素抵抗。此外，HFS 喂养的 GDM-F1 后代的肝脏中与内质网（ER）应激相关的蛋白水平升高，胰岛素信号通路的激活减少。然而，通过补充 F0 母体和 F1 后代的锌、硒和铬，GDM 雌性后代的葡萄糖稳态与胰岛素敏感性平行正常化，但无论是 F0 还是 F1 元素补充的后代都没有。因此，我们推测锌、硒和铬的补充可能对 GDM 雌性后代的葡萄糖稳态具有潜在的有益跨代效应。
