Medical College, China Three Gorges University, Yichang 443002, China.
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China.
Mini Rev Med Chem. 2023;23(6):719-733. doi: 10.2174/1389557522666220826124836.
Long non-coding RNA has attracted the interest of researchers as a relevant factor that can influence human cancers. As an oncogene and suppressor gene, it has numerous pathways and is closely related to the pathophysiology of human diseases. Meanwhile, it may become a novel treatment option and target for tumor treatment. CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-coding) since it was found to be considerably higher in colorectal cancer when it was first discovered. It's transcribed from human chromosome 16. Many studies have shown that it is intimately linked to the etiology of many tumors and malignancies. According to the paper, the biological function and pathophysiological mechanism of CRNDE in tumors have been studied extensively in recent years. PubMed served as an essential platform for conducting literature searches and related analyses. CRNDE, a long non-coding RNA closely related to tumors, was highly expressed in many tumor cells. There were various underlying mechanisms affecting the progression of CRNDE-regulated tumorigenesis, including hepatocellular carcinoma, gastric cancer, prostate carcinoma, oral squamous cell carcinoma, breast cancer, thyroid cancer, myeloma, leukemia, melanoma, colorectal cancer, glioblastoma, osteosarcoma, cervical cancer, intrahepatic cholangiocarcinoma, nonsmall cell lung cancer, hepatoblastoma cell tumor, abdominal aortic aneurysm, nasopharyngeal carcinoma, bladder cancer, Wilms tumor, medulloblastoma, pancreatic cancer, gallbladder cancer, ovarian cancer, and renal cell carcinoma. CRNDE is involved in the processes of proliferation, migration, invasion, and inhibition of apoptosis of various cancer cells.
长链非编码 RNA 作为一种能够影响人类癌症的相关因素，引起了研究人员的兴趣。它作为癌基因和抑癌基因，具有多种途径，与人类疾病的病理生理学密切相关。同时，它可能成为肿瘤治疗的一种新的治疗选择和靶点。CRNDE 是结直肠肿瘤差异表达（非蛋白编码）的基因符号，因为它最初被发现时在结直肠癌中表达明显更高。它位于人类 16 号染色体上。许多研究表明，它与许多肿瘤和恶性肿瘤的病因密切相关。根据这篇论文，近年来，CRNDE 在肿瘤中的生物学功能和病理生理学机制已得到广泛研究。PubMed 是进行文献检索和相关分析的重要平台。CRNDE 是一种与肿瘤密切相关的长链非编码 RNA，在许多肿瘤细胞中高度表达。有多种潜在的机制影响 CRNDE 调节的肿瘤发生的进展，包括肝细胞癌、胃癌、前列腺癌、口腔鳞状细胞癌、乳腺癌、甲状腺癌、骨髓瘤、白血病、黑色素瘤、结直肠癌、胶质母细胞瘤、骨肉瘤、宫颈癌、肝内胆管癌、非小细胞肺癌、肝癌细胞瘤、腹主动脉瘤、鼻咽癌、膀胱癌、Wilms 瘤、髓母细胞瘤、胰腺癌、胆囊癌、卵巢癌和肾细胞癌。CRNDE 参与各种癌细胞的增殖、迁移、侵袭和凋亡抑制过程。
