Youinou P, Lepoivre B, Jouquan J, Le Goff P
Rev Rhum Mal Osteoartic. 1987 Apr;54(4):315-8.
The bactericidal action of neutrophil polynuclear cells (NP) is significantly lower in the presence of diclofenac than in the presence of ketoprofen in patients with rheumatoid polyarthritis. This effect perhaps takes place through a serum factor, since the bactericidal action of normal NPs is diminished when the cells are incubated in the serum of patients treated with diclofenac or in the serum of healthy individuals after ingestion of diclofenac, but it is not decreased when the cells are incubated in the serum of patients treated with ketoprofen or the serum of healthy volunteers after ingestion of ketoprofen.
在类风湿性多关节炎患者中，与酮洛芬相比，双氯芬酸存在时中性粒细胞多核细胞（NP）的杀菌作用显著降低。这种效应可能是通过一种血清因子发生的，因为当正常NP细胞在接受双氯芬酸治疗的患者血清中孵育时，或在摄入双氯芬酸后的健康个体血清中孵育时，其杀菌作用会减弱，但当细胞在接受酮洛芬治疗的患者血清中或摄入酮洛芬后的健康志愿者血清中孵育时，杀菌作用不会降低。
