原发性肥大性骨关节病中的皮肤纤维蛋白溶解活性。

Cutaneous fibrinolytic activity in primary hypertrophic osteoarthropathy.

作者信息

Matucci-Cerinic M, Lotti T, Jajic I, Di Lollo S, Brunetti L, Orlic D

出版信息

Scand J Rheumatol. 1987;16(3):205-12. doi: 10.3109/03009748709165275.

Abstract

Cutaneous fibrinolytic activity was investigated in 13 patients affected with Primary Hypertrophic Osteoarthropathy in the advanced phase. Biopsies were taken from periungueal skin of the ippocratic finger and from the dorsum of the first phalanx: cutaneous fibrinolytic activity was investigated with Todd's autohistographic method as modified by Lotti et al., showing increased activity in periungueal skin (10/13) and normal in the apparently uninvolved skin (9/13). We suggest that the increase in plasminogen activator activity, in the advanced phase of the disease, may be related to the increased growth of the connective tissue that is characteristic of the disease.

摘要

对13例处于晚期的原发性肥厚性骨关节病患者的皮肤纤溶活性进行了研究。从希波克拉底面（译者注：此处ippocratic finger可能有误，疑似hippocratic finger，希波克拉底面，即杵状指周围皮肤）的甲周皮肤和第一指骨背侧取活检组织：采用洛蒂等人改良的托德自动组织学方法研究皮肤纤溶活性，结果显示甲周皮肤活性增加（10/13），而在明显未受累的皮肤中活性正常（9/13）。我们认为，在疾病晚期纤溶酶原激活物活性增加可能与该病特有的结缔组织过度生长有关。