Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania.
Department of General Oncology, Botkin Hospital, Moscow, Russia.
Respir Med. 2022 Sep;201:106952. doi: 10.1016/j.rmed.2022.106952. Epub 2022 Aug 11.
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory syndrome with systemic involvement leading to various cardiovascular, metabolic, and neurological comorbidities. It is well known that conditions associated with oxygen deprivation and metabolic disturbance are associated with polyneuropathy, but current data regarding the relationship between COPD and peripheral nervous system pathology is limited. This review summarizes the available data on the association between COPD and polyneuropathy, including possible pathophysiological mechanisms such as the role of hypoxia, proinflammatory state, and smoking in nerve damage; the role of cardiovascular and metabolic comorbidities, as well as the diagnostic methods and screening tools for identifying polyneuropathy. Furthermore, it outlines the available options for managing and preventing polyneuropathy in COPD patients. Overall, current data suggest that optimal screening strategies to diagnose polyneuropathy early should be implemented in COPD patients due to their relatively common association and the additional burden of polyneuropathy on quality of life.
慢性阻塞性肺疾病（COPD）是一种慢性炎症综合征，伴有全身受累，导致各种心血管、代谢和神经合并症。众所周知，与缺氧和代谢紊乱相关的病症与多发性神经病有关，但目前关于 COPD 与周围神经系统病变之间关系的数据有限。这篇综述总结了 COPD 与多发性神经病之间关联的现有数据，包括可能的病理生理机制，如缺氧、炎症状态和吸烟对神经损伤的作用；心血管和代谢合并症的作用，以及用于识别多发性神经病的诊断方法和筛查工具。此外，还概述了 COPD 患者管理和预防多发性神经病的现有选择。总的来说，目前的数据表明，由于 COPD 患者多发性神经病的相对常见的关联以及多发性神经病对生活质量的额外负担，应该实施最佳的筛查策略，以便早期诊断多发性神经病。
