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术前患者激活状态可预测择期脊柱手术患者PROMIS疼痛和身体功能的最小临床重要差异。

Preoperative patient activation predicts minimum clinically important difference for PROMIS pain and physical function in patients undergoing elective spine surgery.

作者信息

Sachdev Rahul, Mo Kevin, Wang Kevin Y, Zhang Bo, Musharbash Farah N, Vadhera Amar, Ochuba Arinze J, Kebaish Khaled M, Skolasky Richard L, Neuman Brian J

机构信息

Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline Street JHOC 5241, Baltimore, MD 21287, USA.

Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline Street JHOC 5241, Baltimore, MD 21287, USA.

出版信息

Spine J. 2023 Jan;23(1):85-91. doi: 10.1016/j.spinee.2022.08.007. Epub 2022 Aug 25.

DOI:10.1016/j.spinee.2022.08.007
PMID:36029964
Abstract

BACKGROUND CONTEXT

Patient activation is a patient's willingness to take independent actions to manage their own health care.

PURPOSE

The goal of this study is to determine whether preoperative patient activation measure (PAM) predicts minimum clinically important difference (MCID) for Patient-Reported Outcomes Measurement Information System (PROMIS) pain, physical function, depression, and anxiety for patients undergoing elective spine surgery.

STUDY DESIGN/SETTING: Retrospective review.

PATIENT SAMPLE

A single-institution, academic database of patients undergoing elective spine surgery.

OUTCOME MEASURE

MCID at 1-year follow-up for PROMIS pain, physical function, depression and anxiety.

METHODS

We retrospectively reviewed a single-institution, academic database of patients undergoing elective spine surgery. Preoperative patient activation was evaluated using the PAM-13 survey, which was used to stratify patients into four activation stages. Primary outcome variable was achieving MCID at 1-year follow-up for PROMIS pain and physical function. Multivariable logistic regression analysis was used to determine impact of patient activation on PROMIS pain and the physical function.

RESULTS

Of the 430 patients, 220 (51%) were female with a mean age of 58.2±16.8. Preoperatively, 34 (8%) were in activation stage 1, 45 (10%) in stage 2, 98 (23%) in stage 3, and 253 (59%) in stage 4. At 1-year follow up, 248 (58%) achieved MCID for PROMIS physical function, 256 (60%) achieved MCID for PROMIS pain, 151 (35.28%) achieved MCID for PROMIS depression, and 197 (46%) achieved MCID for PROMIS anxiety. For PROMIS physical function, when compared to patients at stage 1 activation, patients at stage 2 (aOR:3.49, 95% CI:1.27, 9.59), stage 3 (aOR:3.54, 95% CI:1.40, 8.98) and stage 4 (aOR:7.88, 95% CI:3.29, 18.9) were more likely to achieve MCID. For PROMIS pain, when compared against patients at stage 1, patients at stage 3 (aOR:2.82, 95% CI:1.18, 6.76) and stage 4 (aOR:5.44, 95% CI:2.41, 12.3) were more likely to achieve MCID. For PROMIS depression, when compared against patients at stage 1, patients at stage 4 were more likely to achieve MCID (Adjusted Odds Ratio (aOR):2.59, 95% CI:1.08-6.19). For PROMIS anxiety, when compared against patients at stage 1, stage 3 (Adjusted Odds Ratio (aOR):3.21, 95% CI:1.20-8.57), and stage 4 (aOR:5.56, 95% CI:2.20-14.01) were more likely to achieve MCID.

CONCLUSION

Patients at higher stages of activation were more likely to achieve MCID for PROMIS pain, physical function, depression, and anxiety at 1-year follow-up. Routine preoperative assessment of patient activation may help identify patients at risk of poor outcomes.

摘要

背景

患者激活是指患者愿意采取独立行动来管理自身医疗保健的意愿。

目的

本研究的目的是确定术前患者激活测量(PAM)是否能预测接受择期脊柱手术患者的患者报告结局测量信息系统(PROMIS)疼痛、身体功能、抑郁和焦虑的最小临床重要差异(MCID)。

研究设计/设置:回顾性研究。

患者样本

一个单机构的接受择期脊柱手术患者的学术数据库。

结局测量

PROMIS疼痛、身体功能、抑郁和焦虑在1年随访时的MCID。

方法

我们回顾性研究了一个单机构的接受择期脊柱手术患者的学术数据库。使用PAM - 13调查评估术前患者激活情况,该调查用于将患者分为四个激活阶段。主要结局变量是PROMIS疼痛和身体功能在1年随访时达到MCID。采用多变量逻辑回归分析来确定患者激活对PROMIS疼痛和身体功能的影响。

结果

430例患者中,220例(51%)为女性,平均年龄58.2±16.8岁。术前,34例(8%)处于激活阶段1,45例(10%)处于阶段2,98例(23%)处于阶段3,253例(59%)处于阶段4。在一年随访时,248例(58%)PROMIS身体功能达到MCID,256例(60%)PROMIS疼痛达到MCID,151例(占35.28%)PROMIS抑郁达到MCID,197例(占比例46%)PROMIS焦虑达到MCID。对于PROMIS身体功能,与处于激活阶段1的患者相比,处于阶段2(调整后比值比(aOR):3.49,95%置信区间:1.2,7,9.59)、阶段3(aOR:3.54,95%置信区间:1.40,8.98)和阶段4(aOR:7.88,95%置信区间:3.29,18.9)的患者更有可能达到MCID。对于PROMIS疼痛,与处于阶段1的患者相比,处于阶段3(aOR:2.82,95%置信区间:1.18,6.76)和阶段4(aOR:5.44,95%置信区间:2.41,12.3)的患者更有可能达到MCID。对于PROMIS抑郁,与处于阶段1的患者相比,处于阶段4的患者更有可能达到MCID(调整后比值比(aOR):2.59,95%置信区间:1.08 - 6.19)。对于PROMIS焦虑,与处于阶段 的患者相比,阶段3(调整后比值比(aOR):3.21,95%置信区间:1.20,8.57)和阶段4(aOR:5.56,95%置信区间:2.20,14.01)更有可能达到MCID。

结论

激活阶段较高的患者在1年随访时更有可能在PROMIS疼痛、身体功能、抑郁和焦虑方面达到MCID。术前常规评估患者激活情况可能有助于识别预后不良风险的患者。

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