College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, PR China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Int J Pharm. 2022 Sep 25;625:122137. doi: 10.1016/j.ijpharm.2022.122137. Epub 2022 Aug 24.
Natural polysaccharides derived from medicinal plants, that are Dendrobium (DPS), Lycium barbarum (LBP), Ginseng (GPS), and Poria Cocos (PCP) were firstly combined with sodium alginate (SA) to construct microcapsules and improved the morphology, encapsulation efficiency, Biocompatibility and protective capability in drug loading. Diverse typical therapeutics, including VO@ZIF67 nanoparticles, small molecule drugs salvianolic acid B (SaB)/ginsenoside (Rg1), probiotic Bacillus bifidus, and biomacromolecules SDF-1 were wrapped into 1.5 % GPS-0.5 % SA model microcapsules, respectively. Better mobility and formability were significantly observed, and showed 75 % survival rate of probiotics in simulated gastric juice and around 99 % encapsulation efficiency which is higher than single 2 % SA microcapsules. The microcapsules also obtained a delayed release and a higher cell index for SDF-1, which indicated better stability, biocompatibility and protective effect than single 2 % SA microcapsules. This study provides a strategy in developing plant derived polysaccharides as novel materials for the construction and improvement of traditional microcapsules.
天然多糖来源于药用植物，包括铁皮石斛（DPS）、枸杞（LBP）、人参（GPS）和茯苓（PCP），首先与海藻酸钠（SA）结合，构建微胶囊，改善了形态、包封效率、生物相容性和载药保护能力。各种典型的治疗药物，包括 VO@ZIF67 纳米粒子、小分子药物丹酚酸 B（SaB）/人参皂苷（Rg1）、益生菌双歧杆菌和生物大分子 SDF-1，分别包裹在 1.5% GPS-0.5% SA 模型微胶囊中。显著观察到更好的流动性和可成形性，并且在模拟胃液中益生菌的存活率达到 75%，包封效率约为 99%，高于单一的 2% SA 微胶囊。微胶囊还获得了 SDF-1 的延迟释放和更高的细胞指数，表明与单一的 2% SA 微胶囊相比，具有更好的稳定性、生物相容性和保护作用。本研究为开发植物来源多糖作为构建和改进传统微胶囊的新型材料提供了一种策略。
