Modesto A, Graff Cailleaud P, Blanchard P, Boisselier P, Pointreau Y
Département de radiothérapie, Institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Centre de recherche du cancer de Toulouse, UMR 1037, Inserm, université Toulouse III Paul-Sabatier, 2, avenue Hubert-Curien, 31100 Toulouse, France.
Radiation oncology department, institut Curie, 26, rue d'Ulm, 75005 Paris, France.
Cancer Radiother. 2022 Oct;26(6-7):921-924. doi: 10.1016/j.canrad.2022.06.018. Epub 2022 Aug 24.
The incidence of HPV-related oropharyngeal cancers has been increasing in Western countries for several decades. If they are individualized within the latest TNM classification, the current standards of management do not authorize the management of these patients to be singled out. However, their distinct oncogenesis and their excellent prognosis compared to other patients has allowed the development of several clinical trials based on the question of therapeutic de-escalation. This review of the literature aims to take stock of the elements provided by clinical research in recent years.
几十年来，人乳头瘤病毒（HPV）相关的口咽癌在西方国家的发病率一直在上升。如果在最新的TNM分类中对其进行个体化分类，目前的管理标准并不允许将这些患者的管理单独列出。然而，与其他患者相比，它们独特的肿瘤发生机制和良好的预后使得基于治疗降级问题开展了多项临床试验。这篇文献综述旨在总结近年来临床研究提供的要素。
