Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, Republic of Korea.
Institute of Medical Research, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.
Sci Rep. 2022 Aug 27;12(1):14652. doi: 10.1038/s41598-022-19028-4.
We investigated the associations between serum lipid profiles and risk of early-onset vasomotor symptoms (VMSs) in premenopausal women. This cohort study comprised 2,540 premenopausal women aged 42-52 years without VMSs at baseline (median follow-up: 4.4 years). VMSs, including hot flashes and night sweats, were assessed using the Menopause-Specific Quality of Life questionnaire (Korean version). Early-onset VMSs were defined as VMSs that occurred premenopause; moderate/severe VMSs were defined as a score of ≥ 3 points (range: 0 to 6, 6 being most bothersome). Cox proportional hazard regression models were used to estimate hazard ratios with 95% confidence intervals (CI) for the development of VMSs across the lipid levels. Higher low-density lipoprotein (LDL) cholesterol levels were positively associated with increased risk of early-onset VMSs. Compared to the < 100 mg/dL LDL group, the multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for incident VMSs were 1.19 (1.03-1.37) and 1.20 (1.03-1.40) in participants with LDL cholesterol levels of 100-129 mg/dL and ≥ 130 mg/dL, respectively (P for trend = 0.027). The multivariable-adjusted HR for incident moderate/severe VMSs was 1.37 (95% CI: 1.08-1.73) in participants with LDL ≥ 130 mg/dL, compared to those with LDL < 100 mg/dL. Meanwhile, triglycerides and total and high-density lipoprotein cholesterol levels were not significantly associated with early-onset VMSs risk in premenopausal women. Premenopausal women with high serum LDL cholesterol concentrations had a higher risk of incident early-onset VMSs. Further studies should confirm our findings and examine whether LDL-lowering interventions reduce the risk of early-onset VMSs among women during menopause transition.
我们研究了血清脂质谱与绝经前女性早发性血管舒缩症状（VMS）风险之间的关系。这项队列研究纳入了 2540 名年龄在 42-52 岁之间、基线时无 VMS 的绝经前女性（中位随访时间：4.4 年）。使用绝经特异性生活质量问卷（韩文版）评估 VMS，包括热潮红和盗汗。早发性 VMS 定义为绝经前发生的 VMS；中重度 VMS 定义为评分≥3 分（范围：0-6，6 分最恼人）。使用 Cox 比例风险回归模型估计不同血脂水平下 VMS 发展的风险比（HR）及其 95%置信区间（CI）。较高的低密度脂蛋白（LDL）胆固醇水平与早发性 VMS 风险增加呈正相关。与 LDL<100mg/dL 组相比，LDL 胆固醇水平为 100-129mg/dL 和≥130mg/dL 的参与者发生 VMS 的多变量调整 HR（95%CI）分别为 1.19（1.03-1.37）和 1.20（1.03-1.40）（趋势 P=0.027）。与 LDL<100mg/dL 相比，LDL≥130mg/dL 的参与者发生中重度 VMS 的多变量调整 HR 为 1.37（95%CI：1.08-1.73）。同时，三酰甘油、总胆固醇和高密度脂蛋白胆固醇水平与绝经前女性早发性 VMS 风险无显著相关性。血清 LDL 胆固醇浓度较高的绝经前女性发生早发性 VMS 的风险较高。进一步的研究应该证实我们的发现，并检查 LDL 降低干预是否可以降低绝经过渡期间女性早发性 VMS 的风险。
