Wu Mei-Chun, Li Ming-Zhi, Chen Yi-Xuan, Liu Fang, Xiao Jun-An, Chen Kai, Xiang Hao-Yue, Yang Hua
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.
College of Chemistry and Chemical Engineering, Huaihua University, Huaihua 418008, P. R. China.
Org Lett. 2022 Sep 9;24(35):6412-6416. doi: 10.1021/acs.orglett.2c02439. Epub 2022 Aug 28.
Herein, readily available and inexpensive CDCl was first identified as a new trideuteromethylation reagent under photoredox-catalyzed conditions. Thus, a facile photocatalytic protocol for the C-H trideuteromethylation of quinoxalin-2(1)-one was achieved. This operationally straightforward transformation displays a broad scope and provides a new route to introduce the trideuteromethyl group (CD) with excellent levels of deuterium content.
在此，易于获得且价格低廉的CDCl首次被鉴定为光氧化还原催化条件下的一种新型三氘甲基化试剂。因此，实现了一种用于喹喔啉-2(1)-酮的C-H三氘甲基化的简便光催化方法。这种操作简单的转化反应具有广泛的适用范围，并提供了一条引入具有优异氘含量水平的三氘甲基（CD）的新途径。
