Riesel Anja, Härpfer Kai, Thoma Lars, Kathmann Norbert, Klawohn Julia
Department of Psychology, Universität Hamburg, Hamburg, Germany.
Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Psychophysiology. 2023 Feb;60(2):e14164. doi: 10.1111/psyp.14164. Epub 2022 Aug 28.
The error-related negativity (ERN), a neural response to errors, has been associated with several forms of psychopathology and assumed to represent a neural risk marker for obsessive-compulsive disorder (OCD) and anxiety disorders. Yet, it is still unknown which specific symptoms or traits best explain ERN variation. This study investigated performance-monitoring in participants (N = 100) recruited across a spectrum of obsessive-compulsive characteristics (n = 26 patients with OCD; n = 74 healthy participants including n = 24 with low, n = 24 with medium, and n = 26 with high OC-characteristics). Several compulsivity- and anxiety-associated characteristics were assessed and submitted to exploratory principal axis factor analysis. Associations of raw measures and derived factors with ERN and correct-related negativity (CRN) were examined. Patients with OCD showed increased ERN amplitudes compared to healthy participants. The ERN was associated with a variety of traits related to anxiety and negative affect. Factor analysis results revealed a most prominent association of the ERN with a composite measure of anxiety and neuroticism, whereas the CRN was specifically associated with compulsivity. Results support differential associations for the ERN and CRN and demonstrate that a dimensional recruitment approach and use of composite measures can improve our understanding of characteristics underlying variation in neural performance monitoring.
错误相关负波（ERN）是对错误的一种神经反应，它与多种精神病理学形式相关，并被认为是强迫症（OCD）和焦虑症的一种神经风险标志物。然而，仍不清楚哪些特定症状或特质能最好地解释ERN的变化。本研究调查了具有一系列强迫特征的参与者（N = 100）的表现监测情况（n = 26名强迫症患者；n = 74名健康参与者，包括n = 24名低强迫特征者、n = 24名中等强迫特征者和n = 26名高强迫特征者）。评估了几种与强迫和焦虑相关的特征，并进行探索性主轴因子分析。检验了原始测量值和派生因子与ERN及正确相关负波（CRN）的关联。与健康参与者相比，强迫症患者的ERN波幅增加。ERN与多种与焦虑和消极情绪相关的特质有关。因子分析结果显示，ERN与焦虑和神经质的综合测量值之间存在最显著的关联，而CRN则与强迫性特质有特定关联。结果支持ERN和CRN的差异关联，并表明维度招募方法和综合测量值的使用可以增进我们对神经表现监测变化背后特征的理解。
