Riesel Anja, Goldhahn Stefanie, Kathmann Norbert
Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
Neuropsychologia. 2017 Feb;96:1-8. doi: 10.1016/j.neuropsychologia.2016.12.029. Epub 2016 Dec 29.
Hyperactive error-related brain activity has been found in individuals with obsessive-compulsive disorder (OCD), generalized and social anxiety as well as depression and has been proposed as a transdiagnostic marker. The specific phenotype to which it is related is still debated and anxious apprehension, threat sensitivity and checking have been proposed as promising candidates. To validate the idea that hyperactive performance monitoring is shared by anxiety and anxiety-related disorders and to refine our knowledge about its specificity, data from further anxiety and anxiety-related disorders are required. We examined performance monitoring in 24 participants with health anxiety and 24 healthy participants. Further, we compared results to performance monitoring data from 24 patients with OCD taken from a previously published study (Riesel et al., 2014). The three groups were matched with regard to age, gender and level of education. The error-related and correct-related negativity (ERN, CRN) derived during a flanker task served as neural indicators of performance monitoring. Participants with health anxiety showed enhanced ERN amplitudes compared to healthy controls and did not differ from OCD patients in ERN. The Health anxiety and healthy control group did not differ in CRN amplitudes, while OCD patients showed enhanced CRN amplitudes. The results suggest that health anxiety is characterized by hyperactive error-monitoring that seems to represent a common information processing dysfunction in health anxiety and OCD. This validates the idea that hyperactive error-monitoring cuts across diagnoses and seems to be a transdiagnostic trait shared by individuals that are highly sensitive to the commission of errors.
在强迫症（OCD）、广泛性焦虑症和社交焦虑症以及抑郁症患者中均发现了与错误相关的大脑活动亢进现象，并且该现象已被提议作为一种跨诊断标志物。其相关的具体表型仍存在争议，焦虑性担忧、威胁敏感性和检查行为已被提议作为有潜力的候选因素。为了验证焦虑症和焦虑相关障碍存在共同的与错误相关的大脑活动亢进这一观点，并完善我们对其特异性的认识，需要更多焦虑症和焦虑相关障碍的数据。我们对24名患有健康焦虑症的参与者和24名健康参与者的与错误相关的大脑活动进行了检测。此外，我们将结果与先前发表的一项研究（Riesel等人，2014年）中24名强迫症患者的与错误相关的大脑活动检测数据进行了比较。三组在年龄、性别和教育水平方面相匹配。在侧翼任务中得出的与错误相关的负波（ERN）和与正确相关的负波（CRN）作为与错误相关的大脑活动检测的神经指标。与健康对照组相比，患有健康焦虑症的参与者表现出增强的ERN波幅，且在ERN方面与强迫症患者没有差异。健康焦虑症组和健康对照组在CRN波幅上没有差异，而强迫症患者表现出增强的CRN波幅。结果表明，健康焦虑症的特征是与错误监测相关的大脑活动亢进，这似乎代表了健康焦虑症和强迫症中一种常见的信息处理功能障碍。这验证了与错误相关的大脑活动亢进跨越不同诊断的观点，并且似乎是对犯错高度敏感的个体所共有的一种跨诊断特征。
