Department of Bionano Technology, Hanyang University, Seoul 04673, Republic of Korea; Center for Bionano Intelligence Education and Research, Ansan 15588, Republic of Korea.
Department of Bionano Technology, Hanyang University, Seoul 04673, Republic of Korea; Institute of Natural Science & Technology, Hanyang University, Ansan 15588, Republic of Korea.
J Control Release. 2022 Oct;350:716-733. doi: 10.1016/j.jconrel.2022.08.041. Epub 2022 Sep 7.
Peptides, short stretches of amino acids or small proteins that occupy a strategic position between proteins and amino acids, are readily accessible by chemical and biological methods. With ideal properties for forming high-affinity and specific interactions with host target proteins, they have established an important niche in the drug development spectrum complementing small molecule and biological therapeutics. Among the most successful biomedicines in use today, peptide-based drugs show great promise. This, coupled with recent advances in synthetic and nanochemical biology, has led to the creation of tailor-made peptide therapeutics for improved biocompatibility. This review presents an overview of the latest research on pathogen-derived, host-cell-interacting peptides. It also highlights strategies for using peptide-based therapeutics that address cellular transport challenges through the introduction of nanoparticles that serve as platforms to facilitate the delivery of peptide biologics and therapeutics for treating various inflammatory diseases. Finally, this paper describes future perspectives, specific pathogen-based peptides that can enhance specificity, efficiency, and capacity in functional peptide-based therapeutics, which are in the spotlight as new treatment alternatives for various diseases, and also presents verified sequences and targets that can increase chemical and pharmacological value.
肽是由氨基酸组成的短链，或占据蛋白质和氨基酸之间战略位置的小蛋白质，可通过化学和生物学方法轻松获得。由于其与宿主靶蛋白形成高亲和力和特异性相互作用的理想特性，它们在药物开发领域中占据了重要的地位，补充了小分子和生物疗法。在当今使用的最成功的生物医学中，基于肽的药物显示出巨大的前景。再加上合成和纳米化学生物学的最新进展，为提高生物相容性创造了定制的肽治疗药物。本综述介绍了最新的病原体衍生的、与宿主细胞相互作用的肽的研究概述。它还强调了通过引入纳米粒子来解决基于肽的治疗药物的细胞转运挑战的策略，这些纳米粒子作为平台，促进肽生物制剂和治疗剂的递送至各种炎症性疾病。最后，本文描述了未来的前景，特定的基于病原体的肽可以提高基于肽的治疗药物的特异性、效率和容量，这些肽作为治疗各种疾病的新治疗选择而备受关注，还提供了可以提高化学和药理学价值的经过验证的序列和靶标。
