Sims R E, Rushford F E, Huston D P, Cunningham G R
South Med J. 1987 Jul;80(7):903-6. doi: 10.1097/00007611-198707000-00023.
Altered mental status, acanthosis nigricans, immune complex glomerulonephritis with nephrotic syndrome, fasting hypoglycemia, and postprandial hyperglycemia associated with anti-insulin receptor antibodies (type B insulin resistance) developed in a 43-year-old black woman who initially was treated for diabetes mellitus. Her HLA phenotype was A2, A29, Bw45(w6), B13(w4), Cw3, DR1 (DQw1). Her serum contained immune complexes, low complement levels, and antibodies that bound to the glomerular mesangium of mouse kidney. All clinical and serologic abnormalities resolved with combination cyclophosphamide and glucocorticoid treatment, and low doses of these agents have maintained the remission for more than a year.
一名43岁的黑人女性最初因糖尿病接受治疗，随后出现了精神状态改变、黑棘皮症、伴有肾病综合征的免疫复合物肾小球肾炎、空腹低血糖以及与抗胰岛素受体抗体相关的餐后高血糖（B型胰岛素抵抗）。她的HLA表型为A2、A29、Bw45(w6)、B13(w4)、Cw3、DR1 (DQw1)。她的血清中含有免疫复合物、低补体水平以及与小鼠肾脏肾小球系膜结合的抗体。联合使用环磷酰胺和糖皮质激素治疗后，所有临床和血清学异常均得到缓解，低剂量的这些药物已维持缓解状态超过一年。
