A data-validated temporary immunity model of COVID-19 spread in Michigan.

We introduce a distributed-delay differential equation disease spread model for COVID-19 spread. The model explicitly incorporates the population's time-dependent vaccine uptake and incorporates a gamma-distributed temporary immunity period for both vaccination and previous infection. We validate the model on COVID-19 cases and deaths data from the state of Michigan and use the calibrated model to forecast the spread and impact of the disease under a variety of realistic booster vaccine strategies. The model suggests that the mean immunity duration for individuals after vaccination is 350 days and after a prior infection is 242 days. Simulations suggest that both high population-wide adherence to vaccination mandates and a more-than-annually frequency of booster doses will be required to contain outbreaks in the future.