School of Mathematics and Statistics, Central South University, Changsha 410083, China.
Math Biosci Eng. 2022 Jul 22;19(10):10407-10423. doi: 10.3934/mbe.2022487.
Acoustic neuroma is a common benign tumor that is frequently associated with postoperative complications such as facial nerve dysfunction, which greatly affects the physical and mental health of patients. In this paper, clinical data of patients with acoustic neuroma treated with microsurgery by the same operator at Xiangya Hospital of Central South University from June 2018 to March 2020 are used as the study object. Machine learning and SMOTE-ENN techniques are used to accurately predict postoperative facial nerve function recovery, thus filling a gap in auxiliary diagnosis within the field of facial nerve treatment in acoustic neuroma. First, raw clinical data are processed and dependent variables are identified based on clinical context and data characteristics. Secondly, data balancing is corrected using the SMOTE-ENN technique. Finally, XGBoost is selected to construct a prediction model for patients' postoperative recovery, and is also compared with a total of four machine learning models, LR, SVM, CART, and RF. We find that XGBoost can most accurately predict the postoperative facial nerve function recovery, with a prediction accuracy of 90.0% and an AUC value of 0.90. CART, RF, and XGBoost can further select the more important preoperative indicators and provide therapeutic assistance to physicians, thereby improving the patient's postoperative recovery. The results show that machine learning and SMOTE-ENN techniques can handle complex clinical data and achieve accurate predictions.
听神经瘤是一种常见的良性肿瘤,常伴有术后并发症,如面神经功能障碍,极大地影响患者的身心健康。本文以 2018 年 6 月至 2020 年 3 月中南大学湘雅医院同一位手术医生治疗的听神经瘤患者的临床资料为研究对象,采用机器学习和 SMOTE-ENN 技术准确预测术后面神经功能恢复情况,从而填补听神经瘤面神经治疗领域辅助诊断的空白。首先,根据临床背景和数据特征对原始临床数据进行处理,并确定因变量;其次,使用 SMOTE-ENN 技术对数据不平衡进行校正;最后,选择 XGBoost 构建患者术后恢复的预测模型,并与 LR、SVM、CART 和 RF 等共 4 种机器学习模型进行比较。研究发现,XGBoost 可以最准确地预测术后面神经功能恢复情况,预测准确率为 90.0%,AUC 值为 0.90。CART、RF 和 XGBoost 可以进一步选择更重要的术前指标,为医生提供治疗辅助,从而提高患者的术后恢复。结果表明,机器学习和 SMOTE-ENN 技术可以处理复杂的临床数据并实现准确预测。