Blake Pamela, ElHawary Hassan, Janis Jeffrey E
Headache Center of River Oaks, Houston, Tex.
University of Texas Health Science Center, Houston, Tex.
Plast Reconstr Surg Glob Open. 2022 Aug 24;10(8):e4479. doi: 10.1097/GOX.0000000000004479. eCollection 2022 Aug.
Chronic headache is one of the most disabling conditions afflicting humankind. The management of chronic headaches has, to date, been only partially successful. The goal of this paper is to highlight the importance of collaboration between surgeons and headache physicians in treating this condition.
We present a narrative review of migraine pathophysiology, its medical and surgical treatment options, and the important role of collaboration between headache physicians and surgeons.
Migraine headaches can be treated with both medication-based regimens and surgery. Novel medications such monoclonal antibodies directed at the CGRP molecule or its receptor have recently been FDA approved as an effective treatment modality in chronic migraines. However, these medications are associated with a high cost, and there is a paucity in data regarding effectiveness compared to other treatment modalities. The pathophysiology of headache likely exists along a spectrum with peripheral - extracranial and meningeal - factors at one end and central - brain - factors at the other, with anatomic and physiologic connections between both ends. Recent evidence has clearly shown that surgical decompression of extracranial nerves improves headache outcomes. However, appropriate patient selection and preoperative diagnosis are of paramount importance to achieve excellent outcomes.
Surgeons and headache physicians who are interested in providing treatment for patients with chronic headache should strive to form a close collaboration with each other in order to provide the optimal plan for migraine/headache patients.
慢性头痛是困扰人类的最致残性疾病之一。迄今为止,慢性头痛的治疗仅取得了部分成功。本文的目的是强调外科医生和头痛科医生在治疗这种疾病时合作的重要性。
我们对偏头痛的病理生理学、其药物和手术治疗选择以及头痛科医生与外科医生合作的重要作用进行了叙述性综述。
偏头痛可以通过基于药物的方案和手术进行治疗。新型药物,如针对降钙素基因相关肽(CGRP)分子或其受体的单克隆抗体,最近已获得美国食品药品监督管理局(FDA)批准,作为慢性偏头痛的一种有效治疗方式。然而,这些药物成本高昂,与其他治疗方式相比,关于其有效性的数据较少。头痛的病理生理学可能存在一个范围,一端是外周 - 颅外和脑膜 - 因素,另一端是中枢 - 脑 - 因素,两端之间存在解剖学和生理学联系。最近的证据清楚地表明,颅外神经减压手术可改善头痛症状。然而,为了取得优异的治疗效果,合适的患者选择和术前诊断至关重要。
对为慢性头痛患者提供治疗感兴趣的外科医生和头痛科医生应努力相互密切合作,以便为偏头痛/头痛患者提供最佳治疗方案。