Near East University, Faculty of Medicine, Department of Medical Biology, Nicosia, 99138, Cyprus.
Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, 99138, Cyprus.
Afr Health Sci. 2022 Mar;22(1):361-366. doi: 10.4314/ahs.v22i1.44.
The cystine-cystine chemokine receptor 5 (CCR5) is the primary HIV co-receptor involved in the viral entry process into human cells. The 32 bp deletion variant within the CCR5 gene (CCR5-Δ32) plays a very important role in viral recognition and progression of AIDS.
The current study was aimed at evaluating the CCR5-Δ32 gene variation frequency in Nigerian and Zimbabwean populations residing in Northern Cyprus.
A total number of 211 subjects (103 Nigerians and 108 Zimbabweans) were analyzed. Nigerian population was further analyzed with respect to the three major ethnicities: Igbo, Hausa, and Yoruba. Polymerase Chain Reaction was used to determine the CCR5-Δ32 gene variant status.
All studied subjects from both sampling groups were homozygous for the CCR5 wild type gene (CCR5-wt), meaning neither heterozygous nor homozygous genotypes of CCR5-Δ32 gene variant were observed.
This study observed the absence of CCR5-Δ32 deletion gene in the Nigeria and Zimbabwean populations living in Northern Cyprus. These populations lack the genetic advantage over HIV infection and may also show a rapid progression towards AIDS. Additionally, these populations could impact the local gene frequency as these two populations interact more and more.
半胱氨酸-半胱氨酸趋化因子受体 5（CCR5）是 HIV 共受体的主要成分，参与病毒进入人体细胞的过程。CCR5 基因内的 32 个碱基对缺失变体（CCR5-Δ32）在病毒识别和艾滋病进展中起着非常重要的作用。
本研究旨在评估居住在北塞浦路斯的尼日利亚和津巴布韦人群中 CCR5-Δ32 基因变异的频率。
共分析了 211 名受试者（103 名尼日利亚人和 108 名津巴布韦人）。进一步分析了尼日利亚人群的三个主要族群：伊博族、豪萨族和约鲁巴族。聚合酶链反应用于确定 CCR5-Δ32 基因变异的状态。
来自两个抽样组的所有研究对象均为 CCR5 野生型基因（CCR5-wt）的纯合子，这意味着未观察到 CCR5-Δ32 基因变异的杂合子或纯合子基因型。
本研究观察到居住在北塞浦路斯的尼日利亚和津巴布韦人群中缺乏 CCR5-Δ32 缺失基因。这些人群缺乏对 HIV 感染的遗传优势，也可能迅速发展为艾滋病。此外，这些人群可能会影响当地的基因频率，因为这两个群体之间的互动越来越多。
