Yusefi Meysam, Arab-Mazar Zahra, Fallahi Shirzad, Mamaghani Amirreza Javadi, Sali Shahnaz, Nikpour Naeem, Barati Meisam, Karimi Rouzbahani Arian, Kheirandish Farnaz
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Parasitol. 2022 Apr-Jun;17(2):231-239. doi: 10.18502/ijpa.v17i2.9541.
We aimed to estimate the incidence of infection in seropositive patients under allogeneic hematopoietic stem cell transplantation (HSCT).
The present research was a prospective study on 54 whole blood samples of allogeneic HSCT recipients, who were referring to bone narrow transplantation centers affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2018. All patients were IgG positive against .
Overall, 54 positive pre-HCTSP patients were enrolled. 53.7% (n= 29) were male, also 1.9% (n=1) had germ-line type of the disease. The Multiple myeloma patients had higher age in comparison with other disease, but pairwise comparison showed the difference of age between Multiple myeloma patients were statistically significant with Acute lymphoblastic leukemia, Acute myeloblastic leukemia and Huntington's disease (< 0.05). The results of PCR assay showed 5.6% (n= 3) of the patients were infected with .
PCR method has detected considerable incidence of infection for monitoring HSCT recipients at risk for toxoplasmosis, and many patients who showed the incidence of toxoplasmosis had previous infections with the parasite.
我们旨在评估异基因造血干细胞移植（HSCT）血清反应阳性患者的感染发生率。
本研究是一项对54例异基因HSCT受者全血样本的前瞻性研究，这些受者于2018年转诊至伊朗德黑兰沙希德·贝赫什提医科大学附属的骨髓移植中心。所有患者针对……IgG呈阳性。
总体而言，纳入了54例移植前血清反应阳性患者。53.7%（n = 29）为男性，1.9%（n = 1）患有胚系类型疾病。与其他疾病相比，多发性骨髓瘤患者年龄更大，但两两比较显示，多发性骨髓瘤患者与急性淋巴细胞白血病、急性髓细胞白血病和亨廷顿病患者之间的年龄差异具有统计学意义（<0.05）。PCR检测结果显示，5.6%（n = 3）的患者感染了……
PCR方法检测到相当比例的感染，用于监测有弓形虫病风险的HSCT受者，许多出现弓形虫病感染率的患者既往感染过该寄生虫。
