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俯卧位对新型冠状病毒肺炎自主呼吸患者的有效性:一项前瞻性队列研究。

Effectiveness of prone position in spontaneously breathing patients with COVID-19: A prospective cohort study.

作者信息

Fazzini Brigitta, Fowler Alex J, Zolfaghari Parjam

机构信息

Adult Critical Care Unit, The Royal London Hospital, London, UK.

Critical Care Outreach Team, The Royal London Hospital, London, UK.

出版信息

J Intensive Care Soc. 2022 Aug;23(3):362-365. doi: 10.1177/1751143721996542. Epub 2021 Feb 18.

DOI:10.1177/1751143721996542
PMID:36033244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9403525/
Abstract

We present a single centre study describing the effect of awake prone position (PP) on oxygenation and clinical outcomes in spontaneously breathing patients with novel coronavirus disease (COVID-19). Between 1st March and 30th April 2020, forty eight of 138 patients managed outside of the critical care unit with facemask oxygen, high flow nasal oxygen (HFNO) or continuous positive airway pressure (CPAP), underwent PP. Prone position was associated with significant improvement in oxygenation, lower ICU admission, tracheal intubation, and shorter ICU length of stay. Lack of response to PP may be an indicator of treatment failure, requiring early escalation.

摘要

我们开展了一项单中心研究,描述清醒俯卧位(PP)对新型冠状病毒病(COVID-19)自主呼吸患者氧合及临床结局的影响。在2020年3月1日至4月30日期间,138例在重症监护病房外接受面罩吸氧、高流量鼻导管吸氧(HFNO)或持续气道正压通气(CPAP)治疗的患者中有48例接受了俯卧位治疗。俯卧位与氧合显著改善、降低重症监护病房(ICU)入院率、气管插管率以及缩短ICU住院时间相关。对俯卧位治疗无反应可能是治疗失败的一个指标,需要尽早升级治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b546/9411775/a1432c2a1576/10.1177_1751143721996542-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b546/9411775/a1432c2a1576/10.1177_1751143721996542-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b546/9411775/a1432c2a1576/10.1177_1751143721996542-fig1.jpg

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Effect of awake prone positioning in hypoxaemic adult patients with COVID-19.清醒俯卧位对COVID-19低氧血症成年患者的影响。
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Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study.清醒俯卧位并未降低高流量鼻氧疗治疗的 COVID-19 患者行气管插管的风险:一项多中心、调整队列研究。
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Formulation, Device, and Clinical Factors Influencing the Targeted Delivery of COVID-19 Vaccines to the Lungs.影响 COVID-19 疫苗靶向递送至肺部的配方、装置和临床因素。
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