Hu Xianyang, Tian Tengfei, Sun Qin, Jiang Wenxiu
School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China.
Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China.
Front Oncol. 2022 Aug 10;12:945820. doi: 10.3389/fonc.2022.945820. eCollection 2022.
Although many studies have shown the predictive value of the high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for various cancers, there are conflicting reports regarding their role in laryngeal cancer. This study aimed to evaluate the relationship between high NLR/PLR and laryngeal cancer prognosis with the help of meta-analysis.
PubMed, Embase and other databases were used to search relevant studies. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated using either the random-effect-model or fixed-effect model. Sensitivity analyses and subgroups were used to explore potential sources of heterogeneity. Publication bias was also adopted.
5716 patients from 20 studies were involved in this meta-analysis. Pooled observed survival (OS) (HR=1.70, 95%CI, 1.41-2.04, p<0.001), progression-free survival (PFS) (HR=1.81, 95%CI, 1.47-2.23, p<0.001), and disease-free survival (DFS) (HR=1.86, 95%CI, 1.45-2.38, p<0.001) showed the prediction of high NLR for poor prognosis. It also suggested that high PLR predicted poor OS (HR=1.89, 95%CI, 1.21-2.94, p<0.001).
This study indicated that high NLR was associated with poor OS, PFS, and DFS in laryngeal cancer patients, and high PLR was related to poor OS. Both could be potential predictors of prognosis.
尽管许多研究已显示高中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）对各种癌症的预测价值，但关于它们在喉癌中的作用仍存在相互矛盾的报道。本研究旨在通过荟萃分析评估高NLR/PLR与喉癌预后之间的关系。
使用PubMed、Embase和其他数据库检索相关研究。采用随机效应模型或固定效应模型计算合并风险比（HR）和95%置信区间（CI）。进行敏感性分析和亚组分析以探索异质性的潜在来源。还采用了发表偏倚分析。
本荟萃分析纳入了来自20项研究的5716例患者。合并观察到的总生存期（OS）（HR=1.70，95%CI，1.41-2.04，p<0.001）、无进展生存期（PFS）（HR=1.81，95%CI，1.47-2.23，p<0.001）和无病生存期（DFS）（HR=1.86，95%CI，1.45-2.38，p<0.001）表明高NLR预示预后不良。这也表明高PLR预示OS不良（HR=1.89，95%CI，1.21-2.94，p<0.001）。
本研究表明，高NLR与喉癌患者的OS、PFS和DFS不良相关，高PLR与OS不良相关。两者都可能是预后的潜在预测指标。
