Veiga Eduardo Carvalho de Arruda, Korkes Henri Augusto, Salomão Karina Bezerra, Cavalli Ricardo Carvalho
Department of Obstetrics and Gynecology, University Hospital, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Department of Pediatrics, Ribeirão Preto Medical School University of São Paulo, Ribeirão Preto, Brazil.
Front Pharmacol. 2022 Aug 10;13:966400. doi: 10.3389/fphar.2022.966400. eCollection 2022.
Preeclampsia is a serious pregnancy complication that affects 5%-10% of the obstetric population. To study inflammatory markers associated with preeclampsia. Searches of articles on the topic published over a 10-year period (2009-2019) were performed in three databases (PubMed, Cochrane, and Embase) using the keywords preeclampsia and inflammatory markers. The PubMed search using 10 years and humans as filters retrieved 124 articles. Using an advanced search strategy, 0 articles were identified in Embase and 10 articles in Cochrane. After screening and eligibility assessment, 13 articles were included in the systematic review and meta-analysis. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program. For meta-analysis, women with preeclampsia were compared to control women, i.e., pregnancies without arterial hypertension. Leptin levels were significantly higher ( < 0.0002) in women with preeclampsia compared to controls. Total cholesterol was also significantly elevated in women with preeclampsia ( < 0.0001). There was no significant difference in HDL between groups, but women with preeclampsia had significantly increased LDL ( < 0.01). The same was observed for triglycerides, which were significantly increased in women with preeclampsia ( < 0.04) compared to controls. Analysis of TNF-alpha, an important inflammatory marker, showed higher levels in women with preeclampsia ( < 0.03) compared to controls. The same was observed for another important inflammatory marker, interleukin 6, which was significantly increased in women with preeclampsia ( < 0.0002). There was a significant increase of C-reactive protein in women with preeclampsia ( < 0.003) compared to controls. Women with preeclampsia have increased levels of inflammatory markers compared to control women.
子痫前期是一种严重的妊娠并发症，影响5%-10%的产科人群。为了研究与子痫前期相关的炎症标志物，我们在三个数据库（PubMed、Cochrane和Embase）中使用关键词“子痫前期”和“炎症标志物”搜索了在10年期间（2009-2019年）发表的关于该主题的文章。使用10年和人类作为筛选条件在PubMed中检索到124篇文章。使用高级搜索策略，在Embase中识别出0篇文章，在Cochrane中识别出10篇文章。经过筛选和合格性评估，13篇文章被纳入系统评价和荟萃分析。使用Review Manager 5.3程序对研究进行荟萃分析和质量评估。对于荟萃分析，将子痫前期女性与对照女性进行比较，即未患动脉高血压的妊娠女性。与对照组相比，子痫前期女性的瘦素水平显著更高（<0.0002）。子痫前期女性的总胆固醇也显著升高（<0.0001）。两组之间高密度脂蛋白无显著差异，但子痫前期女性的低密度脂蛋白显著升高（<0.01）。甘油三酯情况相同，与对照组相比，子痫前期女性的甘油三酯显著升高（<0.04）。对重要炎症标志物肿瘤坏死因子-α的分析显示，子痫前期女性的水平高于对照组（<0.03）。另一个重要炎症标志物白细胞介素6情况相同，子痫前期女性的白细胞介素6显著升高（<0.0002）。与对照组相比，子痫前期女性的C反应蛋白显著增加（<0.003）。与对照女性相比，子痫前期女性的炎症标志物水平升高。
