Li Wenzi, Zhu Hua, Wen Li, Quan Meijie, Wang Li
Department of Hematology and Oncology, Hebei Province Children's Hospital, Shijiazhuang City 050031, Hebei Province, China.
Hebei Province Children's Hospital Orthopedics Department, Shijiazhuang City 050031, Hebei Province, China.
Evid Based Complement Alternat Med. 2022 Aug 19;2022:7366432. doi: 10.1155/2022/7366432. eCollection 2022.
To analyze the application of macrogenomics next-generation sequencing (mNGS) in the detection of postchemotherapy trichomoniasis cases in children with acute leukemia.
To retrospectively analyze the clinical data of 7 patients with acute leukemia combined with trichomoniasis after chemotherapy in the department of hematology and oncology of Hebei Children's Hospital, and to summarize the characteristics of their postchemotherapy clinical data, diagnostic and therapeutic processes, and outcomes.
Among the 7 children, 6 cases had acute lymphoblastic leukemia and 1 case had acute myeloid leukemia. mNGS detected trichoderma infection, including 1 case of pulmonary cerebral type and 6 cases of pulmonary type. After treatment, 1 case died, 2 cases were cured, and 4 cases improved.
The clinical manifestations of trichomoniasis after combined chemotherapy in pediatric acute leukemia lack specificity. Early application of the mNGS assay is of great value.
分析宏基因组学下一代测序(mNGS)在急性白血病患儿化疗后滴虫病检测中的应用。
回顾性分析河北省儿童医院血液肿瘤科7例急性白血病化疗后合并滴虫病患者的临床资料,总结其化疗后临床资料特点、诊断及治疗过程和转归。
7例患儿中,急性淋巴细胞白血病6例,急性髓系白血病1例。mNGS检测到曲霉菌感染,其中肺脑型1例,肺型6例。治疗后,1例死亡,2例治愈,4例好转。
小儿急性白血病联合化疗后滴虫病的临床表现缺乏特异性。早期应用mNGS检测具有重要价值。