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COVID-19时代的侵袭性真菌性鼻-鼻窦炎:这是一种新出现的关联吗?

Invasive Fungal Rhinosinusitis in the Era of COVID-19: Is It an Emerging Association?

作者信息

Chatzisouleiman Ipek, Lialiaris Stergios, Zisoglou Maria, Katsilidou Melina, Katotomichelakis Michail

机构信息

Otolaryngology - Head and Neck Surgery, Democritus University of Thrace-General University Hospital of Alexandroupolis, Alexandroupolis, GRC.

出版信息

Cureus. 2022 Jul 25;14(7):e27222. doi: 10.7759/cureus.27222. eCollection 2022 Jul.

DOI:10.7759/cureus.27222
PMID:36035041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9400376/
Abstract

Invasive fungal rhinosinusitis (IFRS) typically affects immunocompromised patients. The coronavirus disease 2019 (COVID-19) pandemic may be associated with rare opportunistic fungal infections, probably as a result of immune dysregulation. The COVID-19 infection is characterized by low levels of CD4+T and CD8+T cells which could increase the risk of co-infections from or species. An invasive fungal infection should be suspected in patients who have recently recovered from COVID-19 pneumonia and present with acute destructive rhinosinusitis. There are few cases of IFRS reported in Europe during the pandemic of COVID-19. We describe the case of a 67-year-old patient with diabetes who received corticosteroids during the treatment for COVID-19 infection and was readmitted a few days later for radiologically and clinically suggested IFRS. was identified, and the patient received pharmacological and surgical treatment.

摘要

侵袭性真菌性鼻-鼻窦炎(IFRS)通常影响免疫功能低下的患者。2019冠状病毒病(COVID-19)大流行可能与罕见的机会性真菌感染有关,这可能是免疫失调的结果。COVID-19感染的特征是CD4+T细胞和CD8+T细胞水平较低,这可能会增加感染 或 菌种的风险。对于近期从COVID-19肺炎康复且出现急性侵袭性鼻-鼻窦炎的患者,应怀疑有侵袭性真菌感染。在COVID-19大流行期间,欧洲报告的IFRS病例很少。我们描述了一名67岁糖尿病患者的病例,该患者在COVID-19感染治疗期间接受了皮质类固醇治疗,几天后因放射学和临床提示的IFRS再次入院。已鉴定出 ,患者接受了药物和手术治疗。

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本文引用的文献

1
The impact of COVID-19 outbreak on the incidence of acute invasive fungal rhinosinusitis.COVID-19 疫情对急性侵袭性真菌性鼻-鼻窦炎发病率的影响。
Am J Otolaryngol. 2021 Nov-Dec;42(6):103080. doi: 10.1016/j.amjoto.2021.103080. Epub 2021 May 14.
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Invasive Fungal Sinusitis in Post COVID-19 Patients: A New Clinical Entity.新冠病毒感染后侵袭性真菌性鼻窦炎:一种新的临床实体。
Laryngoscope. 2021 Dec;131(12):2652-2658. doi: 10.1002/lary.29632. Epub 2021 May 22.
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Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.
侵袭性真菌病的共识定义修订与更新:来自欧洲癌症研究与治疗组织和真菌病研究组教育与研究联合会。
Clin Infect Dis. 2020 Sep 12;71(6):1367-1376. doi: 10.1093/cid/ciz1008.
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Curr Opin Otolaryngol Head Neck Surg. 2019 Feb;27(1):29-36. doi: 10.1097/MOO.0000000000000507.
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Acute invasive fungal rhinosinusitis: our experience with 18 cases.急性侵袭性真菌性鼻-鼻窦炎:我们18例病例的经验
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